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Design, synthesis and biological evaluation of new Myo-inositol derivatives as potential RAS inhibitors

Hussain, Javeena; Chhabria, Dimple; Kirubakaran, Sivapriya (Elsevier, 2020-08)

Ras is a small family of GTPases that control numerous cellular functions like cell proliferation, growth, survival, gene expression, and is closely engaged in cancer pathogenesis. The ras-targeted methodology entails a ...

Design, synthesis and biological evaluation of new phenothiazine derivatives as potential tousled-like kinase 1 inhibitors in prostate cancer treatment

Bhoir, Siddhant; Singh, Vibha; Hussain, Javeena; Chikhale, Rupesh; Bryce, Richard; Kirubakaran, Sivapriya; De Benedetti, Arrigo (2018-03-29)

Design, synthesis and biological evaluation of new phenothiazine derivatives as potential Tousled-like kinase 1 inhibitors in prostate cancer treatment

Bhoir, Siddhant; Singh, Vibha; Hussain, Javeena; Chikhale, Rupesh; Bryce, Richard; Kirubakaran, Sivapriya; De Benedetti, Arrigo (29-03-19)

Design,synthesis and biological studies of ssmall molecule inhibitors targeting Tousled-like kinase(TLK1/1B) as anti-cancer agent

Sahrawat, Parul; Hussain, Javeena; C. Vaishali; Kirubakaran, Sivapriya (2020-01-22)

Development of small molecule inhibitors targeting rat sarcoma virus

Hussain, Javeena; Bhoir, Siddhant; Kirubakaran, Sivapriya (Japan Advanced Institute of Science and Technology, 2017-03-06)

Development of small-molecule inhibitors targeting RAS

Hussain, Javeena; Shaik, Althaf; Bhoir, Siddhant; Kirubakaran, Sivapriya (2nd National Conference on New Frontiers in Chemistry-from Fundamentals to Applications-II (NFCFA2017), 2017-01-28)

The endeavours in RAS inhibition the past, present, and future

Hussain, Javeena; Kirubakaran, Sivapriya; Ravi, Srimadhavi (Bentham Science Publishers, 2020-09)

KRAS mutations are known to be the most recurrent gain-of-function changes instigated in patients with cancer. The RAS gene family is often mutated in most of the human cancers and the pursuit of inhibitors that bind to ...

Evaluating the therapeutic viability of bacterially expressed human TLK1B-kinase domain for cancer drug design

Johnson, Delna; Hussain, Javeena; Bhoir, Siddhant; Sahsrawat, Parul; Hans, Tanya; Vaishali, C.; Thiruvenkatam, Vijay; Kirubakaran, Sivapriya (Research Square Company, 2022-02)

The role of protein kinases is vital in diverse cellular functions. The alterations in the expression patterns of protein kinases often implicate human cancer initiation and progression. Human Tousled-like kinases (TLKs) ...

Exploring packing features of N-substituted acridone derivatives: synthesis and X-ray crystallography studies

Hussain, Javeena; Sahrawat, Parul; Dubey, Pankaj; Kirubakaran, Sivapriya; Thiruvenkatam, Vijay (Elsevier, 2022-01)

The title compounds include an acridone as a parent molecule in which nitrogen is linked to other nitrogen-containing heterocyclic molecules through two carbon chain alkyl linkers connected by a C-N single bond. These ...

Generation of phenothiazine with potent anti-TLK1 activity for prostate cancer therapy

Singh, Vibha; Bhoir, Siddhant; Chikhale, Rupesh V.; Hussain, Javeena; Dwyer, Donard; Bryce, Richard A.; Kirubakaran, Sivapriya; De Benedetti, Arrigo (Cell Press, 2020-08)

Synthesis and characterization of a new class of phenothiazine molecules with 10H-substituted morpholine & piperidine derivatives: a structural insight

Hussain, Javeena; Angira, Deekshi; Hans, Tanya; Dubey, Pankaj; Kirubakaran, Sivapriya; Thiruvenkatam, Vijay (Elsevier, 2020-06)

A series of 10H-substituted phenothiazine-based molecules were prepared by the base-catalyzed reactions. The synthesized compounds are characterized by Mass spectroscopy, NMR, and SCXRD to examine the role of different ...

Targeting oncogenic ras: the quest for the holy grail in Cancer drug discovery

Hussain, Javeena; Bhoir, Siddhant; Kirubakaran, Sivapriya (Zydus Research Centre, 2017-02-02)

Targeting prostate cancer: the tousled way

Bhoir, Siddhant; Singh, Vibha; Chikhale, Rupesh; Hussain, Javeena; Bryce, Richard; De Benedetti, Arrigo; Kirubakaran, Sivapriya (01-03-20)

Tousled like kinase as a new drug target towards prostate cancer therapy

Bhoir, Siddhant; Hussain, Javeena; Kirubakaran, Sivapriya (22-12-21)

Unravelling the mystery of human tousled-like kinases in cancer

Kirubakaran, Sivapriya; Bhoir, Siddhant; Hussain, Javeena (Indian Institute of Technology Gandhinagar, 2016-12-08)

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