Influence of surface modification on wettability and surface energy characteristics of pharmaceutical excipient powders

Show simple item record

dc.contributor.author Karde, Vikram
dc.contributor.author Ghoroi, Chinmay
dc.date.accessioned 2014-10-20T18:23:28Z
dc.date.available 2014-10-20T18:23:28Z
dc.date.issued 2014-09
dc.identifier.citation Karde, Vikram and Ghoroi, Chinmay, “Influence of surface modification on wettability and surface energy characteristics of pharmaceutical excipient powders”, International Journal of Pharmaceutics, DOI: 10.1016/j.ijpharm.2014.09.002, Sep. 2014. en_US
dc.identifier.issn 0378-5173
dc.identifier.uri http://dx.doi.org/10.1016/j.ijpharm.2014.09.002
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1435
dc.description.abstract Influence of surface modification on wettability and surface energy characteristics of three micron size pharmaceutical excipient powders was studied using hydrophilic and hydrophobic grades of nano-silica. The wetting behavior assessed from contact angle measurements using sessile drop and liquid penetration (Washburn) methods revealed that both techniques showed similar wettability characteristics for all powders depending on the hydrophilic or hydrophobic nature of nano-coating achieved. The polar (γsp) and dispersive (γsd) components of surface energies determined using extended Fowke’s equation with contact angle data from sessile drop method and inverse gas chromatography (IGC) at infinite dilution suggested a general trend of decrease in γsd for all the surface modified powders due to passivation of most active sites on the surface. However, depending on the nature of the functional groups present in nano-silica, γsp was found to be either higher or lower for hydrophilic or hydrophobic coating respectively. Results show that wettability increases with increasing γsp. Both the techniques of surface energy determination provided comparable and similar trends in γsp and γsd components of surface energies for all excipients. The study also successfully demonstrated that surface wettability and energetics of powders can be modified by varying the level of surface coating. en_US
dc.description.statementofresponsibility by Vikram Karde and Chinmay Ghoroi
dc.format.extent vol. 475, no. 1, pp. 351-363
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Contact angle en_US
dc.subject Surface energy en_US
dc.subject Spreading co-efficient en_US
dc.subject Work of adhesion en_US
dc.title Influence of surface modification on wettability and surface energy characteristics of pharmaceutical excipient powders en_US
dc.type Article en_US
dc.relation.journal International Journal of Pharmaceutics


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account