Sodium cyanate mediated synthesis of sulfonylurea and sulfonyltriuret from sulfonyl chloride and amine

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dc.contributor.author Hadianawala, Murtuza
dc.contributor.author Shaik, Althaf
dc.contributor.author Hasija, Nisha
dc.contributor.author Vasu, Anuji K.
dc.contributor.author Datta, Bhaskar
dc.date.accessioned 2016-07-20T10:03:41Z
dc.date.available 2016-07-20T10:03:41Z
dc.date.issued 2016-07
dc.identifier.citation Hadianawala, Murtuza; Shaik, Althaf; Hasija, Nisha; Vasu, Anuji K. and Datta, Bhaskar, “Sodium cyanate mediated synthesis of sulfonylurea and sulfonyltriuret from sulfonyl chloride and amine”, ChemistrySelect, DOI: 10.1002/slct.201600259, vol. 1, no. 10, pp. 2212-2216, Jul. 2016. en_US
dc.identifier.issn 2365-6549
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/2373
dc.identifier.uri http://dx.doi.org/10.1002/slct.201600259
dc.description.abstract Synthetic methods providing access to sulfonylureas are immensely valuable considering the wide usage of sulfonylurea derivatives as hypoglycemic drugs and herbicides. In this work, the scope of a sodium cyanate mediated single-step synthesis of sulfonylureas from amines and sulfonyl chlorides as starting materials has been examined. Success of the single-step reaction in affording desired aliphatic and aromatic sulfonylurea products depends on the combination of suitable nucleophilicity of amines and reactivity of sulfonyl chlorides. In addition to providing access to sulfonylureas, the interplay of reactivities of the amine and sulfonyl chloride is found to result in emergence of specific oligomeric products that are characterized as novel sulfonyltriurets. In effect, the sodium cyanate mediated single-step reaction for synthesis of sulfonylureas also provides a method for synthesis of specific sulfonyltriurets. Electronic effects accompanying the amine and sulfonyl chloride modulate the nature of major product between sulfonylureas and sulfonyltriurets. The sodium cyanate mediated single-step reaction is thus sought to be considered as a method for synthesis of sulfonyltriurets in addition to sulfonylureas. en_US
dc.description.statementofresponsibility by Murtuza Hadianawala, Althaf Shaik, Nisha Hasija, Anuji K. Vasu and Bhaskar Datta
dc.format.extent vol. 1, no. 10, pp. 2212-2216
dc.language.iso en_US en_US
dc.publisher Wiley-Blackwell en_US
dc.subject Sulfonylurea en_US
dc.subject Sulfonyltriuret en_US
dc.subject Sulfonyl chloride en_US
dc.subject Hypoglycemic drugs en_US
dc.subject Herbicides en_US
dc.title Sodium cyanate mediated synthesis of sulfonylurea and sulfonyltriuret from sulfonyl chloride and amine en_US
dc.type Article en_US
dc.relation.journal ChemistrySelect


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