Selective recognition of G-Quadruplexes by a dimeric carbocyanine dye

Show simple item record Chilka, Pallavi Patlolla, Prathap Reddy Prathap Datta, Bhaskar 2016-10-07T08:53:43Z 2016-10-07T08:53:43Z 2016-09
dc.identifier.citation Chilka, Pallavi; Reddy Patlolla, Prathap and Datta, Bhaskar, “Selective recognition of G-Quadruplexes by a dimeric carbocyanine dye”, RSC Advances, DOI: 10.1039/C6RA05474A, vol. 6, no. 90, pp. 87400-87404, Sep. 2016.
dc.identifier.issn 2046-2069
dc.description.abstract A novel dimeric carbocyanine dye is found to recognise G-quadruplex structures selectively compared to mixed sequence or double-stranded DNA molecules. The dye exhibits a preference for G3-bearing parallel quadruplexes and results in a nearly 1400-fold enhancement compared to the absence of DNA and a nearly 30-fold fluorescence enhancement compared to duplex and single stranded DNA molecules. Study of the dye binding with various quadruplex-forming sequences points towards an end-stacking mechanism of interaction. The number of G-quartets and spacer sequences along with the identity of monovalent ions strongly influence the interaction of quadruplexes with the dye. en_US
dc.description.statementofresponsibility by Pallavi Chilka, Patlolla Reddy, Prathap and Bhaskar Datta
dc.format.extent vol. 6, no. 90, pp. 87400-87404
dc.language.iso en_US en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject G-quadruplex en_US
dc.subject carbocyanine dye en_US
dc.title Selective recognition of G-Quadruplexes by a dimeric carbocyanine dye en_US
dc.type Article en_US
dc.relation.journal RSC Advances

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