Green synthesis of 1,4-benzodiazepines over La2O3 and La(OH)3 catalysts: possibility of Langmuir–Hinshelwood adsorption

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dc.contributor.author Palakollu, Veerabhadraiah
dc.contributor.author Singh, Archana
dc.contributor.author Pandey, Aman
dc.contributor.author Kanvah, Sriram
dc.contributor.author Sharma, Sudhanshu
dc.date.accessioned 2016-11-09T07:10:53Z
dc.date.available 2016-11-09T07:10:53Z
dc.date.issued 2016-10
dc.identifier.citation Singh, Archana; Palakollu, Veerabhadraiah; Pandey, Aman; Kanvah, Sriram and Sharma, Sudhanshu, “Green synthesis of 1,4-benzodiazepines over La2O3 and La(OH)3 catalysts: possibility of Langmuir–Hinshelwood adsorption”, RSC Advances, DOI: 10.1039/C6RA22719H, vol. 6, no. 105, pp. 103455-103462, Oct. 2016. en_US
dc.identifier.issn 2046-2069
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/2525
dc.identifier.uri http://dx.doi.org/10.1039/C6RA22719H
dc.description.abstract Lanthanum oxide [La2O3] and lanthanum hydroxide [La(OH)3] have been utilized as bases for the three-component reaction of aldehyde, dimedone and o-phenylenediamine for the synthesis of 1,4-benzodiazepine derivatives. The X-ray diffraction pattern shows pure phase formation of both catalysts. The basicity of La2O3 and La(OH)3 was measured by CO2-TPD (temperature programmed desorption) experiment. The measurements indicate the presence of basic sites that are useful for the reaction. Surface area measurements using Brunauer–Emmett–Teller (BET) reveal a low surface area for both the materials. TEM measurements indicate agglomerated particles with heterogeneous size distribution. The multicomponent reaction also proceeds smoothly in aqueous media as well as organic solvents. The heterogeneous catalyst was successfully recycled for 11 iterations without losing the catalytic activity. Several reactions were performed to understand the mechanism of the adsorption and the experiments suggest that the reaction may possibly proceeds by a Langmuir–Hinshelwood adsorption mechanism. en_US
dc.description.statementofresponsibility by Archana Singh, Veerabhadraiah Palakollu, Aman Pandey, Sriram Kanvah and Sudhanshu Sharma
dc.format.extent Vol. 6, no. 105, pp. 103455-103462
dc.language.iso en_US en_US
dc.publisher RSC Advances en_US
dc.title Green synthesis of 1,4-benzodiazepines over La2O3 and La(OH)3 catalysts: possibility of Langmuir–Hinshelwood adsorption en_US
dc.type Article en_US
dc.relation.journal RSC Advances


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