• Characterization of SPK 98, a Torin2 analog, as ATR and mTOR dual kinase inhibitor 

  Bhakuni, Rashmi; Shaik, Althaf; Priya, Bhanu; Kirubakaran, Sivapriya (Elsevier, 2020-09)

  A series of Torin2, a second-generation ATP-competitive inhibitor, analogues were biologically characterized to identify their potential for ATR and mTOR kinase inhibition. Compound SPK 98 was observed to inhibit ATR/mTOR ...
• An insight of scientific developments in TSC for better therapeutic strategy 

  Natarajan, Nalini; Thiruvenkatam, Vijay (Bentham Science Publishers, 2020-08)

  Tuberous sclerosis complex (TSC) is a rare genetic disease, which is characterized by non-cancerous tumors in multi-organ systems in the body. Mutations in the TSC1 or TSC2 genes are known to cause the disease. The resultant ...
• Higher order networked sliding mode controller for heat exchanger connected via data communication network 

  Shah, Dipesh; Shah, Ankit; Mehta, Axaykumar (Elsevier, 2020-08)

  Heat Exchanger (HE) is a widely used device in industrial applications for both cooling and heating processes because it can sustain a wide range of temperature and pressure parameters without affecting the output performance ...
• Generation of phenothiazine with potent anti-TLK1 activity for prostate cancer therapy 

  Singh, Vibha; Bhoir, Siddhant; Chikhale, Rupesh V.; Hussain, Javeena; Dwyer, Donard; Bryce, Richard A.; Kirubakaran, Sivapriya; De Benedetti, Arrigo (Cell Press, 2020-08)
• CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity 

  Patel, Manthan; Patel, Divyesh; Datta, Subhamoy; Singh, Umashankar (BMC, 2020-07)
• New curcumin-trimesic acid cocrystal and anti-invasion activity of curcumin multicomponent solids against 3D tumor models 

  Sathisaran, Indumathi; Bhatia, Dhiraj; Dalvi, Sameer V. (Elsevier, 2020-09)

  Curcumin (CUR) is a Biopharmaceutics Classification System (BCS) class IV drug with poor aqueous solubility and low permeability. The dissolution of CUR can be enhanced through the cocrystallization approach. In this work, ...
• Nanosheet size-dependent rheology, microstructure, adsorption properties of graphene oxide-electrolyte dispersions and adsorbents 

  Ojha, Abhijeet; Ibrahim, Helen; Alyabyeva, Natalia; Lazzari, Remi; Goldmann, Michel; Thareja, Prachi (Elsevier, 2020-011)

  The variation of lateral dimensions of GO nanosheets by subjecting them to different ultrasonication time (t = 30, 60, and 120 min) influences the rheology, microstructure, and adsorption capacity of graphene oxide (GO) ...
• Recombinant tumor suppressor TSC1 differentially interacts with Escherichia coli DnaK and human HSP70 

  Natarajan, Nalini; Shaik, Althaf; Thiruvenkatam, Vijay (American Chemical Society, 2020-07)

  Tuberous sclerosis complex (TSC) is a neurological syndrome manifested by non-cancerous tumors in several organs. Mutations in either TSC1 or TSC2 tumor suppressor gene cause the disease. In the cell, TSC1 is known to form ...
• A novel sensor for sequential and cellular detection of copper and lactic acid 

  Gour, Nidhi; Kharbanda, Sumit; Pandey, Deepak Kumar; Singh, Dheeraj K.; Bhatia, Dhiraj; Kshtriya, Vivek Shinh; Kanth P., Chandra (ChemRxiv.org, 2020-06)
• Detection of pathological tau conformers in cerebrospinal fluid 

  Gupta, Sharad et al. (FASEB, 2013-04)

  Misfolded tau is a pathological hallmark of over 20 phenotypically distinct neurodegenerative disorders, including Alzheimer's disease (AD). Researchers are beginning to speculate that misfolded tau may spread throughout ...
• Targeting prostate cancer: the tousled way 

  Bhoir, Siddhant; Singh, Vibha; Chikhale, Rupesh; Hussain, Javeena; Bryce, Richard; De Benedetti, Arrigo; Kirubakaran, Sivapriya (01-03-20)
• Nucleic acid based nanoconstructs for environmental analysis in atypical contexts 

  Singhal, Aditi; Kapil, Kriti; Dodla, Ankit; Kumar, Sanjay; Datta, Bhaskar (Springer Nature, 2020)
• Characterization of VopJ by modelling, docking and molecular dynamics simulation with reference to its role in infection of enteropathogen Vibrio parahaemolyticus 

  Raval, Ishan H. et al. (Taylor & Francis, 2020-03)

  Vibrio parahaemolyticus is a renowned enteropathogen known for infecting humans. The infection usually involves various genes which help bacterium bypass the immune system of the host. Type III secretion system (T3SS) is ...
• MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells 

  Singh, Neeru; Bhakuni, Rashmi; Chhabria, Dimple; Kirubakaran, Sivapriya (BMC, 2020-03)
• Comparative analysis of ChIP-exo peak-callers: impact of data quality, read duplication and binding subtypes 

  Sharma, Vasudha; Majumdar, Sharmistha (BMC, 2020-02)

  ChIP (Chromatin immunoprecipitation)-exo has emerged as an important and versatile improvement over conventional ChIP-seq as it reduces the level of noise, maps the transcription factor (TF) binding location in a very ...
• Amyloid like structures from self-assembly of peptide amphiphiles 

  Gadhavi, Joshna; Gupta, Sharad (22-02-20)
• Neurodegenerative disease mutations in KIF1A motor domain and their effect on motility properties 

  Shewale, Dipeshwari; Soppina, Virupakshi (23-01-20)
• Understanding the role of kinesin-3 motors in endocytic pathway 

  Sharma, Surabhi; Patel, Nishaben; Soppina, Virupakshi (23-01-20)
• KIF14: lazy or handicapped? understanding the motility properties of a mitotic motor 

  Siva, Aravintha; Soppina, Virupakshi (23-01-20)
• Molecular mechanism of Rab22a mediated regulation of KIF13A motility and cargo recycling 

  Patel, Nishaben; Sharma, Prerna; Kumari, Ruchi; Siva, Aravintha; Setty, Subba Rao; Soppina, Virupakshi (Biophysical Society, 2020-02)

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