• Nanobiocatalyst facilitated aglycosidic quercetin as a potent inhibitor of tau protein aggregation 

  Kumar, Sanjay; Guru Krishnakumar, V.; Morya, Vinod; Gupta, Sharad; Datta, Bhaskar (Elsevier, 2019-10)

  Polyphenols have been suggested as potential therapeutic agents for the treatment of amyloidogenic diseases. In this work, we evaluate quercetin-rich onion extract for its ability to inhibit tau fibrillization. Considering ...
• Tracing the GSAP-APP C-99 interaction site in the β-amyloid pathway leading to Alzheimer's disease 

  Angira, Deekshi; Chikhale, Rupesh; Mehta, Kapilkumar; Bryce, Richard A.; Thiruvenkatam, Vijay (American Chemical Society, 2019-07)

  Gamma secretase activating protein (GSAP) present in β-amyloid pathway orchestrates the formation of β-amyloid plaques by γ-secretase activation and is an emerging therapeutic target for the treatment of Alzheimer’s disease. ...
• Complex macroscale structures formed by the shock processing of amino acids and nucleobases -- implications to the origins of life 

  Surendra, V S; Jayaram, V; Karthik, S; Vijayan, S; Chandrasekaran, V; Thombre, R; Thiruvenkatam, Vijay; Raja Sekhar, B N; Bhardwaj, A; Jagadeesh, G; Reddy, K P J; Mason, N J; Sivaraman, B (Cornell University Library, 2019-06)

  The building blocks of life, amino acids and nucleobases, are believed to have been synthesized in the extreme conditions that prevail in space starting from simple molecules containing hydrogen, carbon, oxygen and nitrogen. ...
• Investigation of nanoparticle immobilized cellulase: nanoparticle identity, linker length and polyphenol hydrolysis 

  Kumar, Sanjay; Morya, Vinod; Gadhavi, Joshna; Vishnoi, Anjani; Singh, Jaskaran; Datta, Bhaskar (Elsevier, 2019-05)

  Cellulase containing nanobiocatalysts have been useful as an extraction tool based on their ability to disrupt plant cell walls. In this work, we investigate the effect of nanoparticle composition and chemical linkage ...
• Mapping the processivity determinants of the Kinesin-3 motor domain 

  Scarabelli, Guido; Soppina, Virupakshi; Yao, Xin-Qiu; Atherton, Joseph; Moores, Carolyn A.; Verhey, Kristen J.; Grant, Barry J. (Elsevier, 2016-02)
• Elucidating the role of key structural motifs in antifreeze glycoproteins 

  Pandey, Poonam; Mallajosyula, Sairam S. (Royal Society of Chemistry, 2019)

  Antifreeze glycoproteins (AFGPs) are distinctively riveting class of bio-macromolecules, which endows the survival of organisms inhabiting polar and subpolar regions. These proteins are supposed to hinder the microscopic ...
• Distinct DNA sequence preference for histone occupancy in primary and transformed cells 

  Datta, Subhamoy; Patel, Manthan; Patel, Divyesh; Singh, Umashankar (SAGE Journals, 2019-04)

  Genome-wide occupancy of several histone modifications in various cell types has been studied using chromatin immunoprecipitation (ChIP) sequencing. Histone occupancy depends on DNA sequence features like inter-strand ...
• Design, synthesis and optical characterization Of single fluorophore targeting different sub-cellular regions 

  Mukherjee, Tarushyam; Soppina, Virupakshi; Kanvah, Sriram (07-02-2019)
• Effectual template banks for upcoming compact binary searches in Advanced-LIGO and Virgo data 

  Arpag, Goker; Norris, Stephen R.; Mousavi, S. Iman; Soppina, Virupakshi; Verhey, Kristen J.; Hancock, William O.; Tuzel, Erkan (American Physical Society, 2019-01)

  Recent discoveries of gravitational wave (GW) signals from astrophysical compact binary systems of neutron stars and black holes have firmly established them as prime sources for advanced GW detectors. Theoretical templates ...
• Design, synthesis and biological evaluation of Helicobacter pylori inosine 5?-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2 

  Shah, Chetan P.; Purushothaman, Gayathri; Thiruvenkatam, Vijay; Kirubakaran, Sivapriya; Juvale, Kapil; Kharkar, Prashant S (Elsevier, 2019-06)

  Inosine 5′-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) catalyzes a crucial step in guanine nucleotide biosynthesis, thereby governing cell proliferation. In contrast to mammalian IMPDHs, microbial IMPDHs are relatively ...
• Design, synthesis and biological evaluation of new phenothiazine derivatives as potential tousled-like kinase 1 inhibitors in prostate cancer treatment 

  Bhoir, Siddhant; Singh, Vibha; Hussain, Javeena; Chikhale, Rupesh; Bryce, Richard; Kirubakaran, Sivapriya; De Benedetti, Arrigo (2018-03-29)
• Is oligomerization of THAP9 mediated by predicted alpha helical coiled coil regions rich in Leu? 

  Sanghavi, Hiral M.; Majumdar, Sharmistha (2018-11-02)
• Characterization of THAP9 - an immobilized transposon 

  K., Meena; Majumdar, Sharmistha (2018-10-26)
• Characterization of THAP9 - an immobilized transposon 

  K., Meena; Majumdar, Sharmistha (2018-12-21)
• Mechanism of bovine serum albumin aggregation under reduced environment 

  Hivare, Pravin; Guru Krishnakumar, V.; Gupta, Sharad (2019-03-08)
• Effect of carbamylation on aggregation propensity of ?-synuclein 

  Gadhavi, Joshna; Hivare, Pravin; Gupta, Sharad (2019-03-15)
• Tau protein post-translational modification and small molecules interaction: molecular mechanisms of fibrillary assemblies, disassembly and aggregation inhibition 

  Krishankumar, V Guru (Indian Institute of Technology Gandhinagar, 2018)
• Development of a low cost EMG devices to display electrical activity of skeletal muscle on a smartphone 

  Kumar, Sitesh (Indian Institute of Technology Gandhinagar, 2018)
• Functional relevance of histone occupancy at DNA sequence motifs 

  Datta, Subhamoy (Indian Institute of Technology Gandhinagar, 2018)
• Molecular cloning, expression and purification of human tousled like kinase 1B kinase domain (hTLK1B_KD) construct in escherichia coli 

  Raman, Shashank (Indian Institute of Technology Gandhinagar, 2018)

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