Binding sites of the chromatin regulator protein CTCF function as important landmarks in the human genome. The recently characterized CTCF-binding sites at LINE-1 repeats depend on another repeat-regulatory protein CGGBP1. ...
Mukherjee, Tarushyam; Regar, Ramprasad; Soppina, Virupakshi; Kanvah, Sriram(Royal Society of Chemistry, 2021-09)
The 'power house' of the cell mitochondria upsurges significant interest in its investigation of imaging and mapping of the physiological processes. By utilizing sterol-modified rhodamine, we have performed live-cell ...
Parkinson's disease is the second most prevalent neurodegenerative disease. The loss of dopaminergic neurons in the substantia nigra is one of the pathological hallmarks of PD. PD also belongs to the class of neurodegenerative ...
The discovery and development of isoform-selective histone deacetylase (HDAC) inhibitor is a challenging task because of the sequence homology among HDAC enzymes. In the present work, novel tetrahydro benzo[b]thiophene-3 ...
Surendra, V. S.; Jayaram, V.; Muruganantham, M.; Thiruvenkatam, Vijay; Vijayan, S.; Samarth, P.; Hill, H.; Bhardwaj, Anil; Mason, N. J.; Sivaraman, B.(Cambridge University Press, 2021-05)
Nucleobases are nitrogenous bases composed of monomers that are a major constituent of RNA and DNA, which are an essential part of any cellular life on the Earth. The search for nucleobases in the interstellar medium remains ...
Sanghavi, Hiral M.; Majumdar, Sharmistha(American Chemical Society, 2021-05)
Active DNA transposases like the Drosophila P element transposase (DmTNP) undergo oligomerization as a prerequisite for transposition. Human THAP9 (hTHAP9) is a catalytically active but functionally uncharacterized homologue ...
Kshtriya, Vivekshinh; Koshti, Bharti; Pandey, Deepak K.; Kharbanda, Sumit; Kanth P. Chandra; Singh, Dheeraj K.; Bhatia, Dhiraj; Gour, Nidhi(Royal Society of Chemistry, 2021-02)
We report, for the first time, the self-assembly of an acyl-thiourea based sensor, N-{(6-methoxy-pyridine-2-yl) carbamothioyl}benzamide (NG1), with panchromatic fluorescent fibres and its dual-sensing properties for the ...
Ahmed, Jebin; Kumar, Krishan; Sharma, Kedar; Fontes, Carlos M. G. A.; Goyal, Arun(Taylor and Francis, 2021-04)
Pectin is a complex form of polysaccharide and is composed of several structural components that require the concerted action of several pectinases for its complete degradation. In this study, in silico and solution structure ...
Multiple endocytic pathways operate on the plasma membrane of cells at any moment with diverse but specific cellular functions. Knowledge of uptake of synthetic nanoparticles and ligands with respect to endocytic pathways ...
The world we live in today is overpopulated with an unprecedented number of people competing for fewer and fewer precious resources. The struggle to efficiently steward and manage these resources is a global problem in ...
Sathisaran, Indumathi; Dalvi, Sameer V.(American Chemical Society, 2021-04)
Nevirapine (NEV) is an antiretroviral drug which falls under the Biopharmaceutics Classification System (BCS) class II category. In this work, we report the synthesis of new eutectic and cocrystal of NEV with enhanced ...
G-quadruplexes (G4) are the most actively studied non-canonical secondary structures formed by contiguous repeats of guanines in DNA or RNA strands. Small molecule mediated targeting of G-quadruplexes has emerged as an ...
fluorescent sunflower-like architectures. Interestingly, TPA exhibits blue fluorescence in visible light at 385 nm and the fluorescence is not affected by photo-induced quenching rather the fluorescence keeps on increasing ...
We report for the very first time self-assembly of a red color dye 7-Amino-6h-anthra[9,1-cd][1,2]thiazol-6-one (AAT),its photophysical properties and its applications in cell imaging.Interestingly, AAT show intense red ...
Xylan is the major hemicellulose present in sugarcane stem secondary cell walls. Xylan is composed of xylose backbone with a high degree of substitutions, which affects its properties. In the present study, the xylan from ...
Transposable elements function as one of the major effectors in response to biological or environmental stress. Under normal conditions, host organisms deploy epigenetic and post-transcriptional machinery (histone ...