DNA is a polyanionic, hydrophilic, and natural biopolymer that offers properties such as biodegradability, biocompatibility, non-toxicity, and non-immunogenicity. These properties of DNA as an ideal biopolymer offer ...
Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to ...
Cholinium aminoates [Ch][AA] have gained tremendous interest as a promising ionic liquid medium for the synthesis and storage of proteins. However, high alkalinity of [Ch][AA] limits its usage with pH-sensitive proteins. ...
From being genetic material to being exploited as an intelligent biomaterial, DNA has traveled a lot of scientific space of research and innovation. DNA can assemble into macromolecular polymeric networks based on sequences ...
Mayya, Chaithra; Naveena, A. Hema; Sinha, Pankhuri; Wunder, Christian; Johannes, Ludger; Bhatia, Dhiraj(The Company of Biologists, 2022-03)
Endocytosis is indispensable for multiple cellular processes, including signalling, cell adhesion, migration, as well as the turnover of plasma membrane lipids and proteins. The dynamic interplay and regulation of different ...
Naveena, A. Hema; Bhatia, Dhiraj(Cold Spring Harbor Laboratory, 2022-02)
Hypoxia, a decrease in cellular or tissue level oxygen content, is characteristic of most tumours and shown to drive cancer progression by altering multiple subcellular processes. We hypothesized that the cancer cells in ...
Vivek-Ananth, R. P.; Sahoo, Ajaya Kumar; Srivastava, Ashutosh; Samal, Areejit(Royal Society of Chemistry, 2022-02)
Severe fever with thrombocytopenia syndrome virus (SFTSV) causes a highly infectious disease with reported mortality in the range 2.8% to 47%. The replication and transcription of the SFTSV genome is performed by L polymerase, ...
Singh, Udisha; Guduru Teja, Aditya; Walia, Shanka; Vaswani, Payal; Dalvi, Sameer V.; Bhatia, Dhiraj(Royal Society of Chemistry, 2022-01)
Bright fluorescent nanoparticles with excitation and emission towards the red end of the spectrum are highly desirable in the field of bioimaging. We present here a new class of organic carbon-based nanoparticles (CNPs) ...
Rajwar, Anjali; Vaswani, Payal; Bhatia, Dhiraj(Cold Spring Harbor Laboratory, 2022-01)
DNA nanostructures have been explored for capabilities to influence cellular behavior and its functions. Recent times have seen the development of new emergent functionalities of DNA nanodevices as class of biomaterials ...
Genomes of somatic cells in culture are prone to spontaneous mutations due to errors in replication and DNA repair. Some of these errors, such as chromosomal fusions, are not rectifiable and subject to selection or elimination ...
We use two-state ratchet models containing single and coupled Brownian motors to understand the role of motor-microtubule binding, ATPase reaction rate and dimerisation on the translational velocities of Kinesin motors. ...
The global issue of antibiotic resistance has raised various concerns, and there is an urge for the discovery and development of novel antibiotics to control the infection pandemics. The application of nanoparticles in ...
Rajwar, Anjali; Vaswani, Payal; Naveena, A. Hema; Bhatia, Dhiraj(Elsevier, 2022-01)
The field of DNA nanotechnology has diverged into various areas of applications ranging from computing, photonics, biosensing to in vivo bioimaging and therapeutic delivery, to name a few. In the beginning, most of the ...
Dissolution of metal/metal oxide nanoparticles has been widely exploited to be one of the mechanisms of inducing oxidative stress within bacterial and mammalian cells. Elesclomol has been already evaluated in clinical ...
DNA has emerged as one of the smartest biopolymers to bridge the gap between chemical science and biology to design scaffolds like hydrogels by physical entanglement or chemical bonding with remarkable properties. We present ...