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Now showing items 31-50 of 74

Generation of phenothiazine with potent anti-TLK1 activity for prostate cancer therapy

Singh, Vibha; Bhoir, Siddhant; Chikhale, Rupesh V.; Hussain, Javeena; Dwyer, Donard; Bryce, Richard A.; Kirubakaran, Sivapriya; De Benedetti, Arrigo (Cell Press, 2020-08)
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target

Singh, Umashankar (Impact Journals, 2016-01)

Multiple myeloma (MM) is a malignancy of the antibody-producing plasma cells. MM is a highly heterogeneous disease, which has hampered the identification of a common underlying mechanism for disease establishment as well ...
High yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer

Bhoir, Siddhant; Shaik, Althaf; Thiruvenkatam, Vijay; Kirubakaran, Sivapriya (Nature Publishing Group, 2018-03)

Human Tousled-like kinases (TLKs) are highly conserved serine/threonine protein kinases responsible for cell proliferation, DNA repair, and genome surveillance. Their possible involvement in cancer via efficient DNA repair ...
High yield expression of recombinant CD151 in E.coli & a structural insight into cholesterol binding domain

Thiruvenkatam, Vijay (Springer, 2019)
Higher order networked sliding mode controller for heat exchanger connected via data communication network

Shah, Dipesh; Shah, Ankit; Mehta, Axaykumar (Elsevier, 2020-08)

Heat Exchanger (HE) is a widely used device in industrial applications for both cooling and heating processes because it can sustain a wide range of temperature and pressure parameters without affecting the output performance ...
Identification of PfENR inhibitors: a hybrid structure?based approach in conjunction with molecular dynamics simulations

Manhas, Anu; Patel, Anjali; Lone, Mohsin Y.; Jha, Prafulla K.; Jha, Prakash C. (Wiley, 2018-08)

In the current study, we have constructed receptor-based pharmacophore models by exploiting the Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) structural proteome. The derived models were subjected to ...
An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1

Patel, Manthan; Patel, Divyesh; Datta, Subhamoy; Singh, Umashankar (BioMed Central, 2020-12)

Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate ...
Impact of graphene-based nanomaterials (GBNMs) on the structural and functional conformations of hepcidin peptide

Singh, Krishna P.; Baweja, Lokesh; Wolkenhauer, Olaf; Rahman, Qamar; Gupta, Shailendra K. (Springer Verlag, 2018-03)

Graphene-based nanomaterials (GBNMs) are widely used in various industrial and biomedical applications. GBNMs of different compositions, size and shapes are being introduced without thorough toxicity evaluation due to the ...
Influence of phosphorylation on the foamability and stability of bovine serum albumin and citrus peel pectin mixed foams

Modak, Shrikant; Guru, Krishnakumar Viswanathan; Gupta, Sharad; Thareja, Prachi (Taylor & Francis, 2017-09)

We study the influence of phosphorylation on the foamability and stability of Bovine Serum Albumin (BSA), phosphorylated BSA (pBSA) and citrus peel pectin (CPP) mixed foams as a function of BSA – CPP, pBSA – CPP mixing ...
The influence of visual target information on the online control of movements

Sarlegna, Fabrice R.; Mutha, Pratik K. (Elsevier, 2015-05)

The continuously changing properties of our environment require constant monitoring of our actions and updating of our motor commands based on the task goals. Such updating relies upon our predictions about the sensory ...
An insight of scientific developments in TSC for better therapeutic strategy

Natarajan, Nalini; Thiruvenkatam, Vijay (Bentham Science Publishers, 2020-08)

Tuberous sclerosis complex (TSC) is a rare genetic disease, which is characterized by non-cancerous tumors in multi-organ systems in the body. Mutations in the TSC1 or TSC2 genes are known to cause the disease. The resultant ...
Integrating in vitro and in silico approaches to evaluate the "dual functionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils

Haja, Esraa; Loseva, Yelena; Guru, Krishnakumar Viswanathan; Pichinuk, Edward; Engel, Hamutal; Raveh, Avi; Gazit, Ehud; Segal, Daniel (Elsevier, 2018-04)

Background Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (Aβ) peptides in the human brain. ...
Interaction of a dimeric carbocyanine dye aggregate with bovine serum albumin in non-aggregated and aggregated forms

Reddy Patlolla, Prathap; Desai, Nakshi Nayan; Gupta, Sharad; Datta, Bhaskar (Elsevier, 2018-10)

The interaction of fluorescent dyes with serum proteins has garnered significant interest owing to potential for non-covalent labeling and imaging applications. In this work, dimeric benzothiazole-based trimethine cyanine ...
The interaction of flavonols with membrane components: potential effect on antioxidant activity

Saha, Sarmistha; Panieri, Emiliano; Suzen, Sibel; Saso, Luciano (Springer Verlag, 2020-02)

Flavonols are the most widely distributed class of dietary flavonoids with a wide range of pharmacological properties due to their potent lipid peroxidation inhibition activity. The permeability and orientation of these ...
Intranasal exposure to ZnO nanoparticles induces alterations in cholinergic neurotransmission in rat brain

Chakraborty, Swaroop et al. (Elsevier, 2020-12)

The neurotoxicity of inhaled ZnO nanoparticles (NPs) and the underlying mechanisms remain largely unknown. In this study, ZnO NPs (30 � 6 nm) were intranasally instilled to rats via a single dose (13 mg Zn/kg BW), with ...
Investigation of nanoparticle immobilized cellulase: nanoparticle identity, linker length and polyphenol hydrolysis

Kumar, Sanjay; Morya, Vinod; Gadhavi, Joshna; Vishnoi, Anjani; Singh, Jaskaran; Datta, Bhaskar (Elsevier, 2019-05)

Cellulase containing nanobiocatalysts have been useful as an extraction tool based on their ability to disrupt plant cell walls. In this work, we investigate the effect of nanoparticle composition and chemical linkage ...
Mapping the processivity determinants of the Kinesin-3 motor domain

Scarabelli, Guido; Soppina, Virupakshi; Yao, Xin-Qiu; Atherton, Joseph; Moores, Carolyn A.; Verhey, Kristen J.; Grant, Barry J. (Elsevier, 2016-02)
MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells

Singh, Neeru; Bhakuni, Rashmi; Chhabria, Dimple; Kirubakaran, Sivapriya (BMC, 2020-03)
Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids

Guru, Krishnakumar Viswanathan; Paul, Ashim; Segal, Daniel (Nature Publishing Group, 2018-01)

Intra-cellular tau protein tangles and extra-cellular ?-amyloid plaques are hallmarks of Alzheimer's disease (AD), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded ?-sheet rich ...
Molecular mechanism of Rab22a mediated regulation of KIF13A motility and cargo recycling

Patel, Nishaben; Sharma, Prerna; Kumari, Ruchi; Siva, Aravintha; Setty, Subba Rao; Soppina, Virupakshi (Biophysical Society, 2020-02)

Now showing items 31-50 of 74

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