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Now showing items 19-38 of 47

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target

Singh, Umashankar (Impact Journals, 2016-01)

Multiple myeloma (MM) is a malignancy of the antibody-producing plasma cells. MM is a highly heterogeneous disease, which has hampered the identification of a common underlying mechanism for disease establishment as well ...
High yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer

Bhoir, Siddhant; Shaik, Althaf; Thiruvenkatam, Vijay; Kirubakaran, Sivapriya (Nature Publishing Group, 2018-03)

Human Tousled-like kinases (TLKs) are highly conserved serine/threonine protein kinases responsible for cell proliferation, DNA repair, and genome surveillance. Their possible involvement in cancer via efficient DNA repair ...
High yield expression of recombinant CD151 in E.coli & a structural insight into cholesterol binding domain

Thiruvenkatam, Vijay (Springer, 2019)
Identification of PfENR inhibitors: a hybrid structure?based approach in conjunction with molecular dynamics simulations

Manhas, Anu; Patel, Anjali; Lone, Mohsin Y.; Jha, Prafulla K.; Jha, Prakash C. (Wiley, 2018-08)

In the current study, we have constructed receptor-based pharmacophore models by exploiting the Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) structural proteome. The derived models were subjected to ...
Impact of graphene-based nanomaterials (GBNMs) on the structural and functional conformations of hepcidin peptide

Singh, Krishna P.; Baweja, Lokesh; Wolkenhauer, Olaf; Rahman, Qamar; Gupta, Shailendra K. (Springer Verlag, 2018-03)

Graphene-based nanomaterials (GBNMs) are widely used in various industrial and biomedical applications. GBNMs of different compositions, size and shapes are being introduced without thorough toxicity evaluation due to the ...
Influence of phosphorylation on the foamability and stability of bovine serum albumin and citrus peel pectin mixed foams

Modak, Shrikant; Guru, Krishnakumar Viswanathan; Gupta, Sharad; Thareja, Prachi (Taylor & Francis, 2017-09)

We study the influence of phosphorylation on the foamability and stability of Bovine Serum Albumin (BSA), phosphorylated BSA (pBSA) and citrus peel pectin (CPP) mixed foams as a function of BSA – CPP, pBSA – CPP mixing ...
The influence of visual target information on the online control of movements

Sarlegna, Fabrice R.; Mutha, Pratik K. (Elsevier, 2015-05)

The continuously changing properties of our environment require constant monitoring of our actions and updating of our motor commands based on the task goals. Such updating relies upon our predictions about the sensory ...
Integrating in vitro and in silico approaches to evaluate the "dual functionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils

Haja, Esraa; Loseva, Yelena; Guru, Krishnakumar Viswanathan; Pichinuk, Edward; Engel, Hamutal; Raveh, Avi; Gazit, Ehud; Segal, Daniel (Elsevier, 2018-04)

Background Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (Aβ) peptides in the human brain. ...
Interaction of a dimeric carbocyanine dye aggregate with bovine serum albumin in non-aggregated and aggregated forms

Reddy Patlolla, Prathap; Desai, Nakshi Nayan; Gupta, Sharad; Datta, Bhaskar (Elsevier, 2018-10)

The interaction of fluorescent dyes with serum proteins has garnered significant interest owing to potential for non-covalent labeling and imaging applications. In this work, dimeric benzothiazole-based trimethine cyanine ...
Investigation of nanoparticle immobilized cellulase: nanoparticle identity, linker length and polyphenol hydrolysis

Kumar, Sanjay; Morya, Vinod; Gadhavi, Joshna; Vishnoi, Anjani; Singh, Jaskaran; Datta, Bhaskar (Elsevier, 2019-05)

Cellulase containing nanobiocatalysts have been useful as an extraction tool based on their ability to disrupt plant cell walls. In this work, we investigate the effect of nanoparticle composition and chemical linkage ...
Mapping the processivity determinants of the Kinesin-3 motor domain

Scarabelli, Guido; Soppina, Virupakshi; Yao, Xin-Qiu; Atherton, Joseph; Moores, Carolyn A.; Verhey, Kristen J.; Grant, Barry J. (Elsevier, 2016-02)
Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids

Guru, Krishnakumar Viswanathan; Paul, Ashim; Segal, Daniel (Nature Publishing Group, 2018-01)

Intra-cellular tau protein tangles and extra-cellular ?-amyloid plaques are hallmarks of Alzheimer's disease (AD), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded ?-sheet rich ...
Motor Adaptation Deficits in Ideomotor Apraxia

Mutha, Pratik K.; Stapp, Lee H.; Sainburg, Robert L.; Haaland, Kathleen Y. (Cambridge University Press, 2017-02)

Objectives: The cardinal motor deficits seen in ideomotor limb apraxia are thought to arise from damage to internal representations for actions developed through learning and experience. However, whether apraxic patients ...
Nanobiocatalyst facilitated aglycosidic quercetin as a potent inhibitor of tau protein aggregation

Kumar, Sanjay; Guru, Krishnakumar Viswanathan; Morya, Vinod; Gupta, Sharad; Datta, Bhaskar (Elsevier, 2019-10)

Polyphenols have been suggested as potential therapeutic agents for the treatment of amyloidogenic diseases. In this work, we evaluate quercetin-rich onion extract for its ability to inhibit tau fibrillization. Considering ...
The Neuropsychology of movement and movement disorders: neuroanatomical and cognitive considerations

Haaland, Kathleen Y.; Dum, Richard P.; Mutha, Pratik K.; Strick, Peter L.; Tröster, Alexander I. (Cambridge University Press, 2018-10)

This paper highlights major developments over the past two to three decades in the neuropsychology of movement and its disorders. We focus on studies in healthy individuals and patients, which have identified cognitive ...
P Transposable Elements in Drosophila and other Eukaryotic Organisms

Majumdar, Sharmistha; Rio, Donald C. (American Society for Microbiology, 2015-04)

P transposable elements were discovered in Drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. Hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the ...
Piperazine and DBU: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis

Ralhan, Krittika; Guru, Krishnakumar Viswanathan; Gupta, Sharad (Royal Society of Chemistry, 2015-11)

In Solid Phase Peptide Synthesis (SPPS), contamination with deletion sequences which often co-elute with the target peptide continues to be a major challenge as these impurities can significantly affect the target peptide’s ...
Prediction of horseshoe configuration in neural receptors: Dscam isoforms

Thiruvenkatam, Vijay; Chen, Qiang; Wang, Jia-huai (Wiley, 2014-11)

Dscam (Down Syndrome Cell Adhesion Molecule), a member of immunoglobulin superfamily (IgSF), is a receptor for netrin-1 [1,2], a classical axon guidance cue. The interaction between netrin-1 and Dscam plays an important ...
Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation

Morozova, Olga A.; Gupta, Sharad; Colby, David W. (Science Direct, 2015-07-08)

Many neurodegenerative diseases are associated with deposits of aggregated protein in the brain. The molecular pathways through which soluble proteins misfold to form amyloids and large protein aggregates often include ...
Propagation of forcing and model uncertainties on to hydrological drought characteristics in a multi-model century-long experiment in large river basins

Samaniego, Luis; Kumar, R.; Breuer, L.; Chamorro, Alejandro; Flörke, M.; Pechlivanidis, Ilias G.; Schäfer, D.; Shah, H.; Vetter, T.; Wortmann, Michel; Zeng, Xiaofan (Spriger, 2017-04)

Recent climate change impact studies studies have presented conflicting results regarding the largest source of uncertainty in essential hydrological variables, especially streamflow and derived characteristics that describe ...

Now showing items 19-38 of 47

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