Coevolution pattern and functional conservation or divergence of miR167s and their targets across diverse plant species

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dc.contributor.author Suvakanta, Barik
dc.contributor.author Kumar, Ashutosh
dc.contributor.author Das, Shabari sarkar
dc.contributor.author Yadav, Sandeep
dc.contributor.author Gautam, Vibhav
dc.contributor.author Singh, Archita
dc.contributor.author Singh, Sharmila
dc.contributor.author Ananda K.
dc.date.accessioned 2017-11-12T10:28:20Z
dc.date.available 2017-11-12T10:28:20Z
dc.date.issued 2017-10
dc.identifier.citation Barik, Suvakanta; Kumar, Ashutosh; Das, Shabari Sarkar; Yadav, Sandeep; Gautam, Vibhav; Singh, Archita; Singh, Sharmila and Sarkar, Ananda K., “Coevolution pattern and functional conservation or divergence of miR167s and their targets across diverse plant species”, Scientific Reports, DOI: 10.1038/srep14611, vol. 5, 13, Oct. 2015. en_US
dc.identifier.issn 2045-2322
dc.identifier.uri http://dx.doi.org/10.1038/srep14611
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/3269
dc.description.abstract microRNAs (miRNAs), a class of endogenously produced small non-coding RNAs of 20–21 nt length, processed from precursor miRNAs, regulate many developmental processes by negatively regulating the target genes in both animals and plants. The coevolutionary pattern of a miRNA family and their targets underscores its functional conservation or diversification. The miR167 regulates various aspects of plant development in Arabidopsis by targeting ARF6 and ARF8. The evolutionary conservation or divergence of miR167s and their target genes are poorly understood till now. Here we show the evolutionary relationship among 153 MIR167 genes obtained from 33 diverse plant species. We found that out of the 153 of miR167 sequences retrieved from the “miRBase”, 27 have been annotated to be processed from the 3′ end, and have diverged distinctively from the other miR167s produced from 5′ end. Our analysis reveals that gma-miR167h/i and mdm-miR167a are processed from 3′ end and have evolved separately, diverged most resulting in novel targets other than their known ones, and thus led to functional diversification, especially in apple and soybean. We also show that mostly conserved miR167 sequences and their target AUXIN RESPONSE FACTORS (ARFs) have gone through parallel evolution leading to functional diversification among diverse plant species. en_US
dc.description.statementofresponsibility by Suvakanta Barik, Ashutosh Kumar, Shabari Sarkar Das, Sandeep Yadav, Vibhav Gautam, Archita Singh, Sharmila Singa and Ananda K. Sarkar
dc.format.extent vol. 5
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.title Coevolution pattern and functional conservation or divergence of miR167s and their targets across diverse plant species en_US
dc.type Article en_US


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