One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

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dc.contributor.author Nagaraju, Sakkani
dc.contributor.author Satyanarayana, Neeli
dc.contributor.author Paplal, Banoth
dc.contributor.author Vasu, Anuji K.
dc.contributor.author Kanvah, Sriram
dc.contributor.author Sridhar, Balasubramanian
dc.contributor.author Sripadi, Prabhakar
dc.contributor.author Kashinath, Dhurke
dc.date.accessioned 2017-12-06T05:29:04Z
dc.date.available 2017-12-06T05:29:04Z
dc.date.issued 2015-10
dc.identifier.citation Nagaraju, Sakkani; Satyanarayana, Neeli; Paplal, Banoth; Vasu, Anuji K.; Kanvah, Sriram; Sridhar, Balasubramanian; Sripadi, Prabhakar and Kashinath, Dhurke, "One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions", RSC Advances, DOI: 10.1039/C5RA16721C, vol. 5, no. 114, pp. 94474-94478, Oct. 2015. en_US
dc.identifier.issn 2046-2069
dc.identifier.uri http://dx.doi.org/10.1039/C5RA16721C
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/3300
dc.description.abstract One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions of aldehydes, 1,4-dithiane-2,5-diol and 3,5-dimethyl-4-nitroisoxazole. From the base and solvent screening, it was found that piperidine (30 mol%) and ethanol are the most suitable conditions giving the desired products with >95% yields in 2-2.5 h overall reaction time.
dc.description.statementofresponsibility by Sakkani Nagaraju, Neeli Satyanarayana, Banoth Paplal, Anuji K. Vasu, Sriram Kanvah, Balasubramanian Sridhar, Prabhakar Sripadid and Dhurke Kashinath
dc.format.extent vol. 5, no. 114, pp. 94474-94478
dc.language.iso en en_US
dc.publisher Royal Society of Chemistry en_US
dc.title One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions en_US
dc.type Article en_US
dc.relation.journal RSC Advances


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