Effect of co-crystallization on physico-chemical properties of gefitinib

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dc.contributor.author Palanisamy, Parimaladevi
dc.contributor.author Shaik, Althaf
dc.contributor.author Kirubakaran, Sivapriya
dc.contributor.author Thiruvenkatam, Vijay
dc.date.accessioned 2018-01-08T12:33:52Z
dc.date.available 2018-01-08T12:33:52Z
dc.date.issued 2017-08
dc.identifier.citation Palanisamy, Parimaladevi; Shaik, Althaf; Kirubakaran, Sivapriya and Thiruvenkatam, Vijay, "Effect of co-crystallization on physico-chemical properties of gefitinib", Acta Crystallographica Section A, DOI: 10.1107/S2053273317088490, vol. 73, no. a2, pp. C725, Aug. 2017. (Abstract) en_US
dc.identifier.issn 2053-2733
dc.identifier.uri http://dx.doi.org/10.1107/S2053273317088490
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/3378
dc.description.abstract Well-controlled crystallization of the API's (Active Pharmaceutical Ingredients) is often an important factor in pharmaceuticalindustries. The development of new crystallization methods to design the products with specific physico-chemical propertiesis a complex and challenging issue. This existing challenge impetus us to explore the possible ways to control thecrystallization of gefitinib. Gefitinib, [N-(3-chloro-4-fluro-phenyl)-7-methoxy-6-(3-morpholin-4-yl propoxy) quinazolin-4-amine] is an anticancer drug used in the treatment of non-small cell lung cancer. Gefitinib exists in five polymorphic forms (i)anhydrous (ii) solvate of MeOH (iii) solvate of DMSO, (iv) monohydrate and (v) trihydrate forms. Each polymorph hasdifferent physical properties and leads to large variation in the biopharmaceutical performance. The bioavailability of puregefitinib is low and there is a need to enhance the solubility. With this regard, our aim is to isolate the more specificcrystalline polymorph of gefitinib and to enhance the solubility of the preferred form. Here we present, the effect of selectiveamino acids used for co-crystallization with gefitinib and the results will be discussed in detail.
dc.description.statementofresponsibility by Parimaladevi Palanisamy, Althaf Shaik, Sivapriya Kirubakaran and Vijay Thiruvenkatam
dc.format.extent vol. 73, no. a2, pp. C725
dc.language.iso en en_US
dc.publisher International Union of Crystallography en_US
dc.subject Polymorphism en_US
dc.subject gefitinib en_US
dc.subject bioavailability en_US
dc.title Effect of co-crystallization on physico-chemical properties of gefitinib en_US
dc.type Article en_US
dc.relation.journal Acta Crystallographica Section A


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