Template-free self-assembly of dimeric dicarbocyanine dyes

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dc.contributor.author Reddy Patlolla, Prathap
dc.contributor.author Mallajosyula, Sairam Swaroop
dc.contributor.author Datta, Bhaskar
dc.date.accessioned 2018-01-30T11:28:21Z
dc.date.available 2018-01-30T11:28:21Z
dc.date.issued 2017-11
dc.identifier.citation Reddy Patlolla, Prathap; Mallajosyula, Sairam S. and Datta, Bhaskar, "Template-free self-assembly of dimeric dicarbocyanine dyes", ChemistrySelect, DOI:10.1002/slct.201702045, vol. 2, no. 33, pp. 10709-10717, Nov. 2017. en_US
dc.identifier.issn 23656549
dc.identifier.uri http://dx.doi.org/10.1002/slct.201702045
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/3431
dc.description.abstract Symmetrical dicarbocyanine dyes are known to cooperatively assemble on DNA templates. With the goal of developing dyes that are capable of template-free self-assembly, two N-linked dimeric benzothiazole containing pentamethine cyanine dyes have been synthesized. UV-visible spectroscopy of the dimeric dyes reveals very strong propensities for self-assembly unlike their monomeric dye counterparts. The N-propyl linked dye exhibits pronounced H-aggregation at micromolar dye concentrations with the absorption maxima blue-shifted by nearly 200?nm. In contrast, an N-hexyl linked dye preferentially folds into H-dimers. Similar aggregates of the monomeric dicarbocyanine dyes are known to be observed at much higher dye concentrations or in presence of suitable templates such as DNA molecules. The aggregate species of the dimeric dyes are identified based on shifts in their absorbance maxima and quenched fluorescence. The calculated electronic structure of the dimeric dyes supports their observed aggregation behaviour. Further, introduction of DNA molecules with AT-tracts leads to transformation of the spontaneously formed dimeric dye H-aggregates and H-dimers into DNA-bound dye species.
dc.description.statementofresponsibility by Prathap Reddy Patlolla, Sairam S. Mallajosyula and Bhaskar Datta
dc.format.extent vol. 2, no. 33, pp. 10709-10717
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.title Template-free self-assembly of dimeric dicarbocyanine dyes en_US
dc.type Article en_US
dc.relation.journal ChemistrySelect

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