A “Turn-Off” Red-emitting fluorophore for nanomolar detection of Heparin

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dc.contributor.author Jana, Palash
dc.contributor.author Radhakrishna, Mithun
dc.contributor.author Khatua, Saumyakanti
dc.contributor.author Kanvah, Sriram
dc.date.accessioned 2018-02-13T10:09:41Z
dc.date.available 2018-02-13T10:09:41Z
dc.date.issued 2018-02
dc.identifier.citation Jana, Palash; Radhakrishna, Mithun; Khatua, Saumyakanti and Kanvah, Sriram, “A “Turn-Off” Red-emitting fluorophore for nanomolar detection of Heparin”, Physical Chemistry Chemical Physics, DOI: 10.1039/C7CP06300H, Feb. 2018. en_US
dc.identifier.issn 1463-9076
dc.identifier.issn 1463-9084
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/3448
dc.identifier.uri http://dx.doi.org/10.1039/C7CP06300H
dc.description.abstract A simple fluorophore bearing a diethylaminocoumarin donor and a pyridinium acceptor was synthesized and utilized for the ultra-sensitive detection of heparin. The synthesized dicationic push–pull coumarin derivative emits strongly in the red-region (665 nm) and detects nanomolar concentrations (14.8 nM to 148 nM) of heparin in HEPES buffer and FBS serum solutions. The dication exhibits excellent fluorescence selectivity and sensitivity towards heparin over its analogues such as chondroitin 4-sulfate (CS), hyaluronic acid (HA) and dextran. This fluorescence assay is a convenient, sensitive method for monitoring heparin levels in biological samples. These findings were confirmed using coarse-grained Monte Carlo simulations, which provide us with a rationale for the selective binding of heparin. en_US
dc.description.statementofresponsibility by Palash Jana, Mithun Radhakrishna, Saumyakanti Khatuaa and Sriram Kanvah
dc.language.iso en en_US
dc.publisher Royal Society of Chemistry en_US
dc.title A “Turn-Off” Red-emitting fluorophore for nanomolar detection of Heparin en_US
dc.type Article en_US
dc.relation.journal Physical Chemistry Chemical Physics


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