Oxidation of phenothiazine based fluorescent probe for hypochlorite and its application to live cell imaging

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dc.contributor.author Vedamalai, Mani
dc.contributor.author Kedaria, Dhaval
dc.contributor.author Vasita, Rajesh
dc.contributor.author Gupta, Iti
dc.date.accessioned 2018-02-23T10:11:44Z
dc.date.available 2018-02-23T10:11:44Z
dc.date.issued 2018-02
dc.identifier.citation Vedamalai, Mani; Kedaria, Dhaval; Vasita, Rajesh and Gupta, Iti, “Oxidation of phenothiazine based fluorescent probe for hypochlorite and its application to live cell imaging”, Sensors and Actuators B: Chemical, DOI: 10.1016/j.snb.2018.02.071, Feb. 2018. en_US
dc.identifier.issn 0925-4005
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/3476
dc.identifier.uri http://dx.doi.org/10.1016/j.snb.2018.02.071
dc.description.abstract New phenothiazine appended BODIPY derivative has been synthesized and characterized for the determination of hypochlorite in live cells. The fluorescent probe has exhibited 72 fold fluorescence enhancement upon addition of hypochlorite over other reactive oxygen species. Further, the studies proved that the probe has ability to detect the hypochlorite even at extremely low level (4.1 nM). Having less cytotoxicity and negligible auto-fluorescence, the probe was successfully used to monitor external addition and internal secretion of hypochlorite in RAW 264.7 cells. en_US
dc.description.statementofresponsibility Mani Vedamalaia, Dhaval Kedaria, Rajesh Vasita and Iti Gupta
dc.format.extent Vol.265,pp.137-142
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject BODIPY en_US
dc.subject Fluorescent probe en_US
dc.subject Hypochlorite en_US
dc.subject Myeloperoxidase en_US
dc.subject Phenothiazine en_US
dc.title Oxidation of phenothiazine based fluorescent probe for hypochlorite and its application to live cell imaging en_US
dc.type Article en_US
dc.relation.journal Sensors and Actuators B: Chemical


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