dc.contributor.author |
Chilka, Pallavi |
|
dc.contributor.author |
Desai, Nakshi |
|
dc.contributor.author |
Datta, Bhaskar |
|
dc.date.accessioned |
2019-03-12T05:31:44Z |
|
dc.date.available |
2019-03-12T05:31:44Z |
|
dc.date.issued |
2019-01 |
|
dc.identifier.citation |
Chilka, Pallavi; Desai, Nakshi and Datta, Bhaskar, "Small molecule fluorescent probes for G-Quadruplex visualization as potential cancer theranostic agents", Molecules, DOI: 10.3390/molecules24040752, vol. 24, no. 4, Jan. 2019. |
en_US |
dc.identifier.uri |
https://doi.org/10.3390/molecules24040752 |
|
dc.identifier.uri |
https://repository.iitgn.ac.in/handle/123456789/4242 |
|
dc.description.abstract |
G-quadruplexes have gained prominence over the past two decades for their role in gene regulation, control of anti-tumour activity and ageing. The physiological relevance and significance of these non-canonical structures in the context of cancer has been reviewed several times. Putative roles of G-quadruplexes in cancer prognosis and pathogenesis have spurred the search for small molecule ligands that are capable of binding and modulating the effect of such structures. On a related theme, small molecule fluorescent probes have emerged that are capable of selective recognition of G-quadruplex structures. These have opened up the possibility of direct visualization and tracking of such structures. In this review we outline recent developments on G-quadruplex specific small molecule fluorescent probes for visualizing G-quadruplexes. The molecules represent a variety of structural scaffolds, mechanism of quadruplex-recognition and fluorescence signal transduction. Quadruplex selectivity and in vivo imaging potential of these molecules places them uniquely as quadruplex-theranostic agents in the predominantly cancer therapeutic context of quadruplex-selective ligands. |
|
dc.description.statementofresponsibility |
by Pallavi Chilka, Nakshi Desai, and Bhaskar Datta, |
|
dc.format.extent |
vol. 24, no. 4 |
|
dc.language.iso |
en |
en_US |
dc.subject |
G-quadruplexes |
en_US |
dc.subject |
G-quadruplex probe |
en_US |
dc.subject |
oncogene promoter |
en_US |
dc.subject |
cancer theranostic |
en_US |
dc.subject |
quadruplex visualization. |
en_US |
dc.title |
Small molecule fluorescent probes for G-Quadruplex visualization as potential cancer theranostic agents |
en_US |
dc.type |
Article |
en_US |
dc.relation.journal |
Small molecule fluorescent probes for G-Quadruplex visualization as potential cancer theranostic agents |
|