Small molecule fluorescent probes for G-Quadruplex visualization as potential cancer theranostic agents

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dc.contributor.author Chilka, Pallavi
dc.contributor.author Desai, Nakshi
dc.contributor.author Datta, Bhaskar
dc.date.accessioned 2019-03-12T05:31:44Z
dc.date.available 2019-03-12T05:31:44Z
dc.date.issued 2019-01
dc.identifier.citation Chilka, Pallavi; Desai, Nakshi and Datta, Bhaskar, "Small molecule fluorescent probes for G-Quadruplex visualization as potential cancer theranostic agents", Molecules, DOI: 10.3390/molecules24040752, vol. 24, no. 4, Jan. 2019. en_US
dc.identifier.uri https://doi.org/10.3390/molecules24040752
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/4242
dc.description.abstract G-quadruplexes have gained prominence over the past two decades for their role in gene regulation, control of anti-tumour activity and ageing. The physiological relevance and significance of these non-canonical structures in the context of cancer has been reviewed several times. Putative roles of G-quadruplexes in cancer prognosis and pathogenesis have spurred the search for small molecule ligands that are capable of binding and modulating the effect of such structures. On a related theme, small molecule fluorescent probes have emerged that are capable of selective recognition of G-quadruplex structures. These have opened up the possibility of direct visualization and tracking of such structures. In this review we outline recent developments on G-quadruplex specific small molecule fluorescent probes for visualizing G-quadruplexes. The molecules represent a variety of structural scaffolds, mechanism of quadruplex-recognition and fluorescence signal transduction. Quadruplex selectivity and in vivo imaging potential of these molecules places them uniquely as quadruplex-theranostic agents in the predominantly cancer therapeutic context of quadruplex-selective ligands.
dc.description.statementofresponsibility by Pallavi Chilka, Nakshi Desai, and Bhaskar Datta,
dc.format.extent vol. 24, no. 4
dc.language.iso en en_US
dc.subject G-quadruplexes en_US
dc.subject G-quadruplex probe en_US
dc.subject oncogene promoter en_US
dc.subject cancer theranostic en_US
dc.subject quadruplex visualization. en_US
dc.title Small molecule fluorescent probes for G-Quadruplex visualization as potential cancer theranostic agents en_US
dc.type Article en_US
dc.relation.journal Small molecule fluorescent probes for G-Quadruplex visualization as potential cancer theranostic agents


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