Enhanced detection using stable isotope enriched 65Cu doped ferrite nanoparticles for tracing studies

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dc.contributor.author Chakraborty, Swaroop
dc.contributor.author Mahadevan, Barath K.
dc.contributor.author Shah, Juhi
dc.contributor.author Panse, Kaustubh
dc.contributor.author Malvi, Bharti
dc.contributor.author Balasubramanian, C.
dc.contributor.author Singh, Sanjay
dc.contributor.author Misra, Superb K.
dc.date.accessioned 2020-02-22T06:10:44Z
dc.date.available 2020-02-22T06:10:44Z
dc.date.issued 2020-05
dc.identifier.citation Chakraborty, Swaroop; Mahadevan, Barath K.; Shah, Juhi; Panse, Kaustubh; Malvi, Bharti; Balasubramanian, C.; Singh, Sanjay and Misra, Superb K., "Enhanced detection using stable isotope enriched 65Cu doped ferrite nanoparticles for tracing studies", Journal of Alloys and Compounds, DOI: 10.1016/j.jallcom.2019.153502, vol. 822, May. 2020. en_US
dc.identifier.issn 0925-8388
dc.identifier.issn 1873-4669
dc.identifier.uri https://doi.org/10.1016/j.jallcom.2019.153502
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5097
dc.description.abstract 65Copper stable isotope doped ferrite nanoparticles with two dopant concentrations were prepared by a co-precipitation method for conducting biomedical experiments at environmentally relevant concentrations. The synthesized (65CuxFe1-xFe2O4) nanoparticles were of 30 � 7 nm in size and the VSM measurements showed a magnetic moment of 30 emu/g of un-doped ferrite particles at 310 K. The amount of 65Cu doped in the ferrite nanoparticles were calculated using ICP-MS. Cytocompatibility studies were performed through cellular toxicity assays on WRL68 liver cell line. MTT and ROS assay demonstrated cell viability in an order of Fe3O4>65Cu0.088Fe2.085O4>65Cu0.143Fe3.31O4. The cytocompatibility and magnetic measurement data set indicate that by doping a small amount of copper, the ferrite nanoparticles can retain their magnetic properties and the cytocompatibility is not severely compromised. 65Cu0.088Fe2.085O4 (d1-Fe3O4) and 65CuO nanoparticles were used for tracing experiments, wherein, even at a lower exposure concentration of 0.5 ?g/mL, 65Cu can be detected in the media even when the copper background concentration is high. The results indicate the ability to perform biological studies at low exposure concentrations with enhanced detection ability. The proposed technique shows that isotope enriched copper doped ferrite can serve the purpose of quantifiable traceable nanocarriers.
dc.description.statementofresponsibility by Swaroop Chakraborty, Barath K. Mahadevan, Juhi Shah, Kaustubh Panse, Bharti Malvi, C. Balasubramanian, Sanjay Singh and Superb K. Misra
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Doping en_US
dc.subject Tracing en_US
dc.subject Ferrite nanoparticles en_US
dc.subject Nanoparticles en_US
dc.subject Stable isotopes en_US
dc.subject Biomedical en_US
dc.subject Applications en_US
dc.title Enhanced detection using stable isotope enriched 65Cu doped ferrite nanoparticles for tracing studies en_US
dc.type Article en_US
dc.relation.journal Journal of Alloys and Compounds

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