Environmentally benign nanoantibiotics with a built-in deactivation switch responsive to natural habitats

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dc.contributor.author Zheng, Wan
dc.contributor.author Anzaldua, Miguel
dc.contributor.author Arora, Ankita
dc.contributor.author Jiang, Yunjiang
dc.contributor.author McIntyre, Kelly
dc.contributor.author Doerfert, Michael
dc.contributor.author Winter, Theodora
dc.contributor.author Mishra, Abhijit
dc.contributor.author Ma, Hairong
dc.contributor.author Liang, Hongjun
dc.date.accessioned 2020-04-07T09:58:47Z
dc.date.available 2020-04-07T09:58:47Z
dc.date.issued 2020-03
dc.identifier.citation Zheng, Wan; Anzaldua, Miguel; Arora, Ankita; Jiang, Yunjiang; McIntyre, Kelly; Doerfert, Michael; Winter, Theodora; Mishra, Abhijit; Ma, Hairong and Liang, Hongjun, “Environmentally benign nanoantibiotics with a built-in deactivation switch responsive to natural habitats”, Biomacromolecules, DOI: 10.1021/acs.biomac.0c00163, vol. 21, no. 6, pp. 2187-2198, Mar. 2020. en_US
dc.identifier.issn 1525-7797
dc.identifier.issn 1526-4602
dc.identifier.uri http://dx.doi.org/10.1021/acs.biomac.0c00163
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5296
dc.description.abstract The massive use of antibiotics in healthcare and agriculture has led to their artificial accumulation in natural habitats, which risks the structure and function of microbial community in ecosystems, threatens food and water security, and accelerates the development of resistome. Ideally, antibiotics should remain fully active in clinical services while become deactivated rapidly once released into environment, but none of the current antibiotics meet this criterion. Here we show a nanoantibiotic design that epitomizes the concept of carrying a built-in "OFF" switch responsive to natural stimuli. The environmentally benign nanoantibiotics consist of cellulose backbones covalently grafted with hydrophilic polymer brushes that by themselves are antimicrobial inactive. In their nanostructured forms in services, these cellulose-based polymer molecular brushes are potent killers for both Gram-positive and Gram-negative bacteria, including clinical multidrug resistant strains; after services and being discharged into environment, they are shredded into antimicrobial-inactive pieces by cellulases that do not exist in human body but are abundant in natural habitats. This study illuminates a new concept of mitigating the environmental footprints of antibiotics with rationally designed nanoantibiotics that can be dismantled and disabled by bioorthogonal chemistry occurring exclusively in natural habitats.
dc.description.statementofresponsibility by Wan Zheng, Miguel Anzaldua, Ankita Arora, Yunjiang Jiang, Kelly McIntyre, Michael Doerfert, Theodora Winter, Abhijit Mishra, Hairong Ma and Hongjun Liang
dc.format.extent vol. 21, no. 6, pp. 2187-2198
dc.language.iso en_US en_US
dc.publisher American Chemical Society en_US
dc.subject Antimicrobial agents
dc.subject Hydrophilicity,
dc.subject Membranes
dc.subject Nanostructures
dc.title Environmentally benign nanoantibiotics with a built-in deactivation switch responsive to natural habitats en_US
dc.type Article en_US
dc.relation.journal Biomacromolecules


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