Seasonality impels the antibiotic resistance in Kelani river of the emerging economy of Sri Lanka

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dc.contributor.author Kumar, Manish
dc.contributor.author Chaminda, G. G. Tushara
dc.contributor.author Honda, Ryo
dc.date.accessioned 2020-04-27T05:22:47Z
dc.date.available 2020-04-27T05:22:47Z
dc.date.issued 2020-04
dc.identifier.citation Kumar, Manish; Chaminda, G. G. Tushara and Honda, Ryo, "Seasonality impels the antibiotic resistance in Kelani river of the emerging economy of Sri Lanka", npj Clean Water, DOI: 10.1038/s41545-020-0058-6, vol. 3, no. 12, Apr. 2020. en_US
dc.identifier.issn 2059-7037
dc.identifier.uri https://doi.org/10.1038/s41545-020-0058-6
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5340
dc.description.abstract We evaluated the occurrence of antibiotic-resistant bacteria, antibiotic-resistant gene, and metal concentration in a tropical river of Sri Lanka as a pre-emptive effort to understand the seasonal impact on their prevalence. Resistance for norfloxacin, ciprofloxacin, levofloxacin, kanamycin monosulfate (KM), tetracycline (TC), and sulfamethoxazole (ST) was measured with Kirby�Bauer disc diffusion method. The prevalence of Escherichia coli ranged from 10 to 27?CFU (colony-forming unit)?ml?1 in Kelani River in Sri Lanka, and most of the E. coli isolates were resistant to more than one antibiotic. However, the resistance for TC and ST was much higher than other antibiotics. We found that the resistance percentage for older antibiotics like TC and ST was higher than the newer antibiotics. We detected genes that confer resistance to TCs, sulfonamides, ?-lactams, and fluoroquinolones. Seasonal variation in the resistance of fluoroquinolones was much higher than the non-fluoroquinolones, but the effect was antagonistic. Overall, the significant seasonal variations imply the importance of mixed source and environmental conditions for development and transmission of antibiotic resistance.
dc.description.statementofresponsibility by Manish Kumar, G. G. Tushara Chaminda and Ryo Honda
dc.language.iso en_US en_US
dc.publisher Nature Research en_US
dc.title Seasonality impels the antibiotic resistance in Kelani river of the emerging economy of Sri Lanka en_US
dc.type Article en_US
dc.relation.journal npj Clean Water


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