BODIPY based red emitters: synthesis, computational and biological studies

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dc.contributor.author Pandey, Vijayalakshmi
dc.contributor.author Raza, Md Kausar
dc.contributor.author Sonowal, Mridupavan
dc.contributor.author Gupta, Itidey, Vijayalakshmi
dc.contributor.author Raza, Md Kausar
dc.contributor.author Sonowal, Mridupavan
dc.contributor.author Gupta, Iti
dc.date.accessioned 2020-12-04T11:08:45Z
dc.date.available 2020-12-04T11:08:45Z
dc.date.issued 2020-11
dc.identifier.citation Pandey, Vijayalakshmi; Raza, Md Kausar; Sonowal, Mridupavan and Gupta, Iti, “BODIPY based red emitters: synthesis, computational and biological studies”, Bioorganic Chemistry, DOI: 10.1016/j.bioorg.2020.104467, vol. 106, Nov. 2020 en_US
dc.identifier.issn 0045-2068
dc.identifier.uri https://doi.org/10.1016/j.bioorg.2020.104467
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/6103
dc.description.abstract Donor-Acceptor type BODIPYs with strong absorption and fluorescence in the red region (550�800 nm) are reported. The aromatic groups like N-butylcarbazole/ N-butylphenothiazine/ benzothiadiazole were attached to the C-8 position of the BODIPY core with furan or thiophene spacers. TD-DFT studies indicated significant charge distribution between C-8 aromatic heterocycles and BODIPY core in all the molecules. The in-vitro studies of the N-butylcarbazole substituted BODIPYs indicated significant localization in the endoplasmic reticulum and lysosomes of the cancer cells. The BODIPYs showed decent cytotoxicity after 48 h incubation period (14.9 to 31.8 ?M) in HeLa and A549 cancer cells, indicating their potential application as theranostic agents.
dc.description.statementofresponsibility by Vijayalakshmi Pandey, Md Kausar Raza, Mridupavan Sonowal and Iti Gupta
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Absorption en_US
dc.subject Emission en_US
dc.subject DFT Studies en_US
dc.subject Bioimaging en_US
dc.subject Carbazole en_US
dc.title BODIPY based red emitters: synthesis, computational and biological studies en_US
dc.type Article en_US
dc.relation.journal Bioorganic Chemistry


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