Water stable, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

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dc.contributor.author Singh, Udisha
dc.contributor.author Guduru Teja, Aditya
dc.contributor.author Walia, Shanka
dc.contributor.author Vaswani, Payal
dc.contributor.author Dalvi, Sameer V.
dc.contributor.author Bhatia, Dhiraj
dc.coverage.spatial United Kingdom
dc.date.accessioned 2022-02-16T08:48:07Z
dc.date.available 2022-02-16T08:48:07Z
dc.date.issued 2022-01
dc.identifier.citation Singh, Udisha; Guduru Teja, Aditya; Walia, Shanka; Vaswani, Payal; Dalvi, Sameer V. and Bhatia, Dhiraj, “Water stable, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake”, Nanoscale Advances, DOI: 10.1039/d1na00813g, vol. 4, no. 5, pp. 1375-1386, Jan. 2022. en_US
dc.identifier.issn 2516-0230
dc.identifier.uri https://doi.org/10.1039/d1na00813g
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/7532
dc.description.abstract Bright fluorescent nanoparticles with excitation and emission towards the red end of the spectrum are highly desirable in the field of bioimaging. We present here a new class of organic carbon-based nanoparticles (CNPs) with a robust quantum yield and fluorescence towards the red region of the spectrum. Using organic substrates such as para-phenylenediamine (PPDA) dispersed in diphenyl ether under reflux conditions, we achieved scalable amounts of CNPs with an average size of 27 nm. These CNPs were readily taken up by different mammalian cells, and we show that they prefer clathrin-mediated endocytosis for their cellular entry route. Not only can these CNPs be specifically taken up by cells, but they also stimulate cellular processes such as cell invasion from 3D spheroid models. This new class of CNPs, which have sizes similar to those of proteinaceous ligands, hold immense potential for their surface functionalization. These could be explored as promising bioimaging agents for biomedical imaging and intracellular drug delivery.
dc.description.statementofresponsibility by Udisha Singh, Aditya Guduru Teja, Shanka Walia, Payal Vaswani, Sameer V. Dalvi and Dhiraj Bhatia
dc.format.extent vol. 4, no. 5, pp. 1375-1386
dc.language.iso en_US en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject Carbon nanoparticles stimulate en_US
dc.subject 3D cell invasion en_US
dc.subject Clathrin-mediated endocytic en_US
dc.subject Fluorescent nanoparticles en_US
dc.subject carbon-based nanoparticles en_US
dc.title Water stable, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake en_US
dc.type Article en_US
dc.relation.journal Nanoscale Advances


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