γ-Resorcyclic acid-based AIEgens for illuminating endoplasmic reticulum

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dc.contributor.author Ingle, Jaypalsing
dc.contributor.author Dedaniya, Hiren
dc.contributor.author Mayya, Chaithra
dc.contributor.author Mondal, Anirban
dc.contributor.author Bhatia, Dhiraj
dc.contributor.author Basu, Sudipta
dc.coverage.spatial United States of America
dc.date.accessioned 2022-03-26T10:11:11Z
dc.date.available 2022-03-26T10:11:11Z
dc.date.issued 2022-03
dc.identifier.citation Ingle, Jaypalsing; Dedaniya, Hiren; Mayya, Chaithra; Mondal, Anirban; Bhatia, Dhiraj and Basu, Sudipta, "γ-Resorcyclic acid-based AIEgens for illuminating endoplasmic reticulum", Chemistry: A European Journal, DOI: 10.1002/chem.202200203, Mar. 2022. en_US
dc.identifier.issn 0947-6539
dc.identifier.issn 1521-3765
dc.identifier.uri https://doi.org/10.1002/chem.202200203
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/7603
dc.description.abstract Endoplasmic reticulum (ER) has emerged as one of the interesting sub-cellular organelles due to its role in myriads of biological phenomena. Subsequently, visualization of the structure-function and dynamics of ER remained a major challenge to understand its involvement in different diseased states including cancer. To illuminate the ER, herein we have designed and synthesized ?-resorcyclic acid-based small molecules which showed remarkable aggregation induced emission (AIE) property in water. This AIE property was originated from the dual intramolecular H-bonding leading to the self-assembled 2D aggregation confirmed by the pH and temperature dependent fluorescence quenching studies as well as scanning electron microscopy. These small molecules illuminated the sub-cellular ER in HeLa cervical cancer cells as well as non-cancerous RPE-1 human retinal epithelial cells within 1h. These novel small molecules have the potential to light up ER chemical biology in diseased states.
dc.description.statementofresponsibility by Jaypalsing Ingle, Hiren Dedaniya, Chaithra Mayya, Anirban Mondal, Dhiraj Bhatia and Sudipta Basu
dc.language.iso en_US en_US
dc.publisher Wiley en_US
dc.subject Endoplasmic reticulum en_US
dc.subject AIEgens en_US
dc.subject HeLa cervical cancer cells en_US
dc.subject RPE-1 en_US
dc.subject Chemical biology en_US
dc.title γ-Resorcyclic acid-based AIEgens for illuminating endoplasmic reticulum en_US
dc.type Article en_US
dc.relation.journal Chemistry: A European Journal


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