Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium

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dc.contributor.author Prajapata, Mahendra Kumar
dc.contributor.author Saini, Supreet
dc.date.accessioned 2014-03-16T13:42:09Z
dc.date.available 2014-03-16T13:42:09Z
dc.date.issued 2012-11
dc.identifier.citation Prajapat, Mahendra Kumar and Saini, Supreet, “Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium”, Computers in Biology and Medicine, DOI: 10.1016/j.compbiomed.2012.09.005, vol. 42, no. 11, pp. 1133–1140, Nov. 2012. en_US
dc.identifier.issn 0010-4825
dc.identifier.uri http://dx.doi.org/10.1016/j.compbiomed.2012.09.005
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/799
dc.description.abstract Salmonella enterica is responsible for a large number of diseases in a wide-range of hosts. Two of the global regulators involved in controlling gene expression during the infection cycle of the bacterium are Fur and HNS. In this paper, we demonstrate computationally that Fur and HNS have disproportionately high density of binding sites in the Pathogenicity Islands on the Salmonella chromosome. Moreover, the frequency of binding sites for the two proteins is correlated throughout the genome of the organism. These results indicate a complex interplay between Fur and HNS in regulating cellular global behavior. en_US
dc.description.statementofresponsibility by Mahendra Kumar Prajapata and Supreet Saini
dc.format.extent Vol. 42, No. 11, pp. 1133–1140
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Fimbriae en_US
dc.subject Flagella en_US
dc.subject Gene expression en_US
dc.subject Salmonella typhimurium en_US
dc.subject Salmonella Pathogenicity Island en_US
dc.subject Transcription factors en_US
dc.title Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium en_US
dc.type Article en_US
dc.relation.journal Computers in Biology and Medicine


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