Pharmaceutical nanotechnology: dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading

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dc.contributor.author Han, Xi
dc.contributor.author Ghoroi, Chinmay
dc.contributor.author Dave, Rajesh N.
dc.date.accessioned 2014-03-17T09:17:40Z
dc.date.available 2014-03-17T09:17:40Z
dc.date.issued 2013-02
dc.identifier.citation Han, Xi; Ghoroi, Chinamy and Dave, Rajesh, “Pharmaceutical nanotechnology: Dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading”, International Journal of Pharmaceutics, DOI: 10.1016/j.ijpharm.2012.08.004, vol. 442, no. 1-2, pp. 74-85, Feb. 2013. en_US
dc.identifier.issn 0378-5173
dc.identifier.uri http://dx.doi.org/10.1016/j.ijpharm.2012.08.004
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/843
dc.description.abstract Motivated by our recent study showing improved flow and dissolution rate of the active pharmaceutical ingredient (API) powders (20 μm) produced via simultaneous micronization and surface modification through continuous fluid energy milling (FEM) process, the performance of blends and direct compacted tablets with high drug loading is examined. Performance of 50 μm API powders dry coated without micronization is also considered for comparison. Blends of micronized, non-micronized, dry coated or uncoated API powders at 30, 60 and 70% drug loading, are examined. The results show that the blends containing dry coated API powders, even micronized ones, have excellent flowability and high bulk density compared to the blends containing uncoated API, which are required for direct compaction. As the drug loading increases, the difference between dry coated and uncoated blends is more pronounced, as seen in the proposed bulk density-FFC phase map. Dry coating led to improved tablet compactibility profiles, corresponding with the improvements in blend compressibility. The most significant advantage is in tablet dissolution where for all drug loadings, the t80 for the tablets with dry coated APIs was well under 5 min, indicating that this approach can produce nearly instant release direct compacted tablets at high drug loadings. en_US
dc.description.statementofresponsibility by Xi Han, Chinmay Ghoroi and Rajesh Dave
dc.format.extent Vol. 442, No. 1-2, pp. 74-85
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject API blends en_US
dc.subject Dry coating en_US
dc.subject Direct compaction en_US
dc.subject Dissolution en_US
dc.subject Ibuprofen en_US
dc.subject Micronization en_US
dc.title Pharmaceutical nanotechnology: dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading en_US
dc.type Article en_US
dc.relation.journal International Journal of Pharmaceutics


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