Role of extracellular cues to trigger the metabolic phase shifting from acidogenesis to solventogenesis in Clostridium acetobutylicum

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dc.contributor.author Kumar, Manish
dc.contributor.author Saini, Supreet
dc.contributor.author Gayen, Kalyan
dc.date.accessioned 2014-03-17T09:48:54Z
dc.date.available 2014-03-17T09:48:54Z
dc.date.issued 2013-06
dc.identifier.citation Kumar, Manish; Gayen, Kalyan and Saini , Supreet, “Role of extracellular cues to trigger the metabolic phase shifting from acidogenesis to solventogenesis in Clostridium acetobutylicum”, Bioresource Technology, DOI: 10.1016/j.biortech.2013.03.159, vol. 138, pp. 55-62, Mar. 2013. en_US
dc.identifier.issn 0960-8524
dc.identifier.uri http://dx.doi.org/10.1016/j.biortech.2013.03.159
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/850
dc.description.abstract Clostridium acetobutylicum exhibits a two-step metabolic pathway where substrates are first converted to organic acids accompanied by a decrease in pH. The acids are then assimilated to organic solvents. The transition from the acid-producing (acidogenesis) to the solvent-producing phase (solventogenesis) is controlled by integration of a number of cellular and environmental cues, whose precise mode of action are not well understood. In this study, a series of batch experiments were performed to understand the impact of extracellular cues in regulating the dynamics of acidogenesis and solventogenesis. It is demonstrated that the two phases operate independently of each other and the growth phase of the cell, i.e. the cues controlling a phase are not linked to the status of the other phase or the growth phase of the cell. Kinetic experiments demonstrated that there exist two previously uncharacterized negative feedback loops controlling the amounts of acids produced in the acidogenesis phase. en_US
dc.description.statementofresponsibility by Manish Kumar, Kalyan Gayen and Supreet Saini
dc.format.extent Vol. 138, pp. 55–62
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Butanol en_US
dc.subject Metabolism en_US
dc.subject Clostridium acetobutylicum en_US
dc.title Role of extracellular cues to trigger the metabolic phase shifting from acidogenesis to solventogenesis in Clostridium acetobutylicum en_US
dc.type Article en_US
dc.relation.journal Bioresource Technology


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