Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA

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dc.contributor.author Kanvah, Sriram
dc.contributor.author Schuster, Gary B.
dc.date.accessioned 2014-03-18T19:45:43Z
dc.date.available 2014-03-18T19:45:43Z
dc.date.issued 2011-02
dc.identifier.citation Kanvah Gundimeda, Sriram and Schuster, G. B., “Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA”, Canadian Journal of Chemistry, DOI: 10.1139/V10-145, vol. 89, no. 3, pp. 326-330, Feb. 2011. en_US
dc.identifier.issn 0008-4042
dc.identifier.issn 1480-3291
dc.identifier.uri http://dx.doi.org/10.1139/V10-145
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/934
dc.description.abstract A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron “hole”) that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines. en_US
dc.description.statementofresponsibility by Sriram Kanvah Gundimeda and Gary B. Schuster
dc.format.extent Vol. 89, No. 3, pp. 326-330
dc.language.iso en en_US
dc.publisher NRC Research Press en_US
dc.subject Anthraquinone photosensitizer en_US
dc.subject Charge transport en_US
dc.subject DNA oxidation en_US
dc.subject Guanidinium backbone en_US
dc.title Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA en_US
dc.type Article en_US
dc.relation.journal Canadian Journal of Chemistry


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