Sharma, ShubhamShubhamSharmaHassan, Muhammad YusufMuhammad YusufHassanBarbhuiya, Noman HanifNoman HanifBarbhuiyaMansukhbhai, Ramolia HarshitRamolia HarshitMansukhbhaiShukla, ChinmayeeChinmayeeShuklaSingh, DeepshikhaDeepshikhaSinghDatta, BhaskarBhaskarDatta2025-08-312025-08-312025-12-0110.1038/s41597-025-05176-52-s2.0-105006757581http://repository.iitgn.ac.in/handle/IITG2025/2798240410205Dysregulated expression of long non-coding RNAs (lncRNAs) in cancer contributes to various hallmarks of the disease, presenting novel opportunities for diagnosis and therapy. G-quadruplexes (G4s) within lncRNAs have gained attention recently; however, their systematic evaluation in cancer biology is yet to be performed. In this work, we have formulated a comprehensive dataset integrating experimentally-validated associations between lncRNAs and cancer, and detailed predictions of their G4-forming potential. The dataset categorizes predicted G4-motifs into anticipated G4 types (2 G, 3 G, and 4 G) and provides information about the subcellular localization of the corresponding lncRNAs. It describes lncRNA-RNA and lncRNA-protein interactions, together with the RNA G4-binding capabilities of these proteins. The dataset facilitates the investigation of G4-mediated lncRNA functions in diverse human cancers and provides distinctive leads about G4-mediated lncRNA-protein interactions.trueArticlehttps://www.nature.com/articles/s41597-025-05176-5.pdf20524463December 20251849arJournal1WOS:001493471200002