Dilip, HarithaHarithaDilipShalini,ShaliniThiruvenkatam, VijayVijayThiruvenkatamKirubakaran, SivapriyaSivapriyaKirubakaran2025-11-262025-11-262025-11-0110.1016/j.drudis.2025.1045052-s2.0-105021052143http://repository.iitgn.ac.in/handle/IITG2025/3352541110544Infectious diseases of bacterial origin currently account for the greatest number of human deaths worldwide, serving as a major hurdle for the growth of many developing nations including the Indian subcontinent. However, identification of potential therapeutic drug targets in infectious pathogens, to facilitate species-selective and target-specific inhibition for the development of effective therapeutic regimens, involves several challenges ranging from the identification and validation of a suitable drug target to overcoming drug toxicity and antimicrobial resistance. This short review is a compilation of a decade of research on the potential antibacterial drug target inosine-5′-monophosphate dehydrogenase (IMPDH) and its therapeutic implications for microbial infections.falsede novo purine biosynthesis | IMPDH | metabolic enzyme | microbial infections | targeted therapyArticle18785832November 20250104505WOS:001612598300001