Mehta, RonakRonakMehtaKumar, RohtashRohtashKumarSingh, SurajSurajSinghAppayee, ChandrakumarChandrakumarAppayee2025-08-312025-08-312024-08-0210.1021/acs.joc.4c012342-s2.0-85199404532http://repository.iitgn.ac.in/handle/IITG2025/28794A general methodology for the asymmetric synthesis of α-arylcyclohexeneones from arylacetones and α,β-unsaturated aldehydes catalyzed by diphenylprolinol silyl ether followed by p-TSA-mediated cyclization is developed. A variety of arylacetones and α,β-unsaturated aldehydes were successfully converted to α-arylcyclohexeneones in 34-67% yield, 10:1-100:0 dr, and 81-99% ee. The scalability of this methodology by a gram-scale synthesis and their utility by converting the product to the corresponding epoxide, alcohol, and diol are demonstrated.falseArticle1520690410892-109022 August 20240arJournal0WOS:001275503900001