Patel, DhruviDhruviPatelVaswani, PayalPayalVaswaniSengupta, SumanaSumanaSenguptaRay, DebesDebesRayBhatia, DhirajDhirajBhatiaChoudhury, Sharmistha DuttaSharmistha DuttaChoudhuryAswal, Vinod K.Vinod K.AswalKuperkar, KetanKetanKuperkarBahadur, PratapPratapBahadur2025-08-312025-08-312023-02-0110.1007/s00396-022-05039-02-s2.0-85143542462http://repository.iitgn.ac.in/handle/IITG2025/25770Self-assembly generation in block copolymers (BCPs): normal Pluronics® (L31, L64, L35, P65) and reverse Pluronics® (31R1, 17R4, 25R4, 10R5) are scrutinized in single/ mixed aqueous environment systems. Solutions up to 10%w/v in investigated systems remained transparent up to ambient temperature while on progressive heating they attained their cloud point (CP). The critical micelle temperature (CMT) was evaluated by fluorescence spectroscopy, which is further complemented by dynamic light scattering (DLS) and small-angle light scattering (SANS). L31 showed phase separation (2ϕ) at ~ 30 °C without any micelle formation. L64, L35, and P65 formed micelles at high temperatures with some growth close to CP while all reverse Pluronics® formed no micelles until CP. The micellar parameters were reinforced from scattering as a function of temperature. Furthermore, these nanoscale micellar aggregates were explored qualitatively and quantitatively as potential nanocargos for anticancer (curcumin) drug to understand the cytotoxic effect using MTT assay. Graphical Abstract: Plausible micellar transition and phase behavior in block copolymers (BCPs) with contrast block structure as a function of temperature.[Figure not available: see fulltext.]falseBlock copolymers (BCPs) | Drug solubilization | Micellar transition | Phase behavior | Scattering profileArticle1435153675-92February 20236arJournal7WOS:000894838400001