Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

Padmaja, Venkata M.D.Venkata M.D.PadmajaJangra, SachinSachinJangraAppayee, ChandrakumarChandrakumarAppayee2025-08-312025-08-312019-01-0110.1039/c8ob02059k2-s2.0-85061481993http://repository.iitgn.ac.in/handle/IITG2025/2339230209495The first α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved under mild reaction conditions. Several α,β,γ,δ-unsaturated aldehydes and diarylcarbinols are successfully tested for the synthesis of MBH-type α-alkylated products with an excellent regioselectivity. Simple pyrrolidine is efficiently used as a catalyst to achieve a perfect E/Z selectivity of the α-alkylated products.falseHighly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydesArticle1714-171720194arJournal4WOS:000458679200012