Upadhyay, AwaneeshAwaneeshUpadhyayDalvi, Sameer V.Sameer V.Dalvi2025-08-302025-08-302019-02-0110.1016/j.ultrasmedbio.2018.09.0222-s2.0-85057795854http://repository.iitgn.ac.in/handle/IITG2025/2266930527395Microbubbles are increasingly being used in biomedical applications such as ultrasonic imaging and targeted drug delivery. Microbubbles typically range from 0.1 to 10 µm in size and consist of a protective shell made of lipids or proteins. The shell encapsulates a gaseous core containing gases such as oxygen, sulfur hexafluoride or perfluorocarbons. This review is a consolidated account of information available in the literature on research related to microbubbles. Efforts have been made to present an overview of microbubble synthesis techniques; microbubble stability; microbubbles as contrast agents in ultrasonic imaging and drug delivery vehicles; and side effects related to microbubble administration in humans. Developments related to the modeling of microbubble dissolution and stability are also discussed.falseCancer therapeutic | Contrast enhancement | Dissolution | Immunogenicity | Lipids | Microbubbles | Modeling | Ostwald ripening | Proteins | Stability | Targeted drug deliveryArticle1879291X301-343February 2019104104WOS:000454875400004