Sarkale, Abhijeet M.Abhijeet M.SarkaleMaurya, VidyasagarVidyasagarMauryaGiri, SachinSachinGiriAppayee, ChandrakumarChandrakumarAppayee2025-08-312025-08-312019-06-0710.1021/acs.orglett.9b014452-s2.0-85067065691https://repository.iitgn.ac.in/handle/IITG2025/2324731140820A direct N-heterocyclic carbene (NHC) catalysis of maleimides with alkyl aldehydes is established for the synthesis of 3-acylsuccinimides. The first dynamic kinetic resolution of 3-acylsuccinimides is accomplished through asymmetric transfer hydrogenation. These two catalytic methodologies are utilized for the synthesis of each enantiomer of trans-paraconic acids in three steps and cis-paraconic acids in four steps with good yields and high stereoselectivities. This stereodivergent synthetic methodology is applied for the synthesis of seven bioactive paraconic acid natural products.en-USfalseArticle152370524266-42707 June 20191414WOS:000471212100083