Kirubakaran, SivapriyaSivapriyaKirubakaranRavi, SrimadhaviSrimadhaviRaviShaik, AlthafAlthafShaikBarui, SugataSugataBarui2025-08-292025-08-292018-10-19https://repository.iitgn.ac.in/handle/IITG2025/20462The present disclosure relates to a quinoline based compounds and a process for preparing the same. The Quinoline based compounds have pharmacokinetic and pharmacodynamics properties which make them potential inhibitors of the PIKK family of kinases, especially ATM, ATR, and DNA-PKcs, which play a vital role in the survival of cancer cells. These quinoline based compounds have a potential to kill the cancer cells preferentially by exploiting the concept of synthetic lethality.en-USChemicalPatents Granted466023[201821039653]123456789/385