Nonsilyl Bicyclic Secondary Amine Catalysts for the Asymmetric Transfer Hydrogenation of α,β-Unsaturated Aldehydes

Kumar, RohtashRohtashKumarMaurya, VidyasagarVidyasagarMauryaAvinash, AvinashAvinashAvinashAppayee, ChandrakumarChandrakumarAppayee2025-08-312025-08-312024-06-2110.1021/acs.joc.4c005232-s2.0-85195325590https://repository.iitgn.ac.in/handle/IITG2025/28867The first chiral synthesis of nonsilyl bicyclic secondary amine organocatalysts and their application to the asymmetric transfer hydrogenation of α,β-unsaturated aldehydes are disclosed. A lower catalytic loading (5 mol %) is demonstrated for the reduction of a wide range of α,β-unsaturated aldehydes (up to 97% yield and up to 99% ee). The application of this scalable methodology is showcased for the asymmetric synthesis of bioactive molecules such as phenoxanol, citronellol, ramelteon, and terikalant.en-USfalseNonsilyl Bicyclic Secondary Amine Catalysts for the Asymmetric Transfer Hydrogenation of α,β-Unsaturated AldehydesArticle152069048586-860021 June 202435WOS:001242750600001