Sharma, RahulRahulSharmaModi, UnnatiUnnatiModiKumar, RahulRahulKumarSharma, ChiragChiragSharmaSrivastav, Amit KumarAmit KumarSrivastavBhatia, DhirajDhirajBhatiaSolanki, RaghuRaghuSolanki2025-08-312025-08-312025-06-0110.1016/j.bioadv.2025.2142352-s2.0-85217912300http://repository.iitgn.ac.in/handle/IITG2025/2811739978287Cancer remains a significant global health challenge, driving the development of advanced platforms for highly targeted and efficient drug delivery. Early-stage nanocarriers, such as synthetic polymeric and inorganic materials, face limitations in biocompatibility and biodegradability. In contrast, bioinspired nanocarriers derived from natural biomacromolecules mimic biological processes and present a promising alternative due to their biocompatibility, biodegradability and non-toxicity. The effectiveness of these drug delivery systems is influenced by factors such as size, shape, surface properties, morphology, functionalization, and preparation methods. Various biomacromolecule-inspired nanocarriers such as protein-based, lipid-based, carbohydrate-based and nucleic acid-based are now at the forefront of research. This review highlights the properties, advantages and limitations of different bioinspired materials. We also explore cutting-edge approaches for cancer therapy using these nanocarriers with recent in-vitro, in-vivo and patent evidence. Finally, we address the challenges and potential solutions associated with bioinspired nanocarriers, proposing future directions. Overall, this review explores nature-inspired drug delivery systems that have paved the way for advancements in cancer therapy.falseBio-inspired nanocarriers | Cancer therapy | Drug deliveryArticle27729508June 20250214235reJournal1WOS:001429379500001