Dynamics and control of the clostridium acetobutylicum metabolic network

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dc.contributor.author Kumar, Manish
dc.contributor.author Gayen, Kalyan
dc.contributor.author Saini, Supreet
dc.contributor.other Clostridium XII International Conference on the Genetics, Physiology and Biotechnology of Solvent and Acid-forming Clostridia
dc.coverage.spatial Nottingham, UK
dc.date.accessioned 2014-04-23T18:18:13Z
dc.date.available 2014-04-23T18:18:13Z
dc.date.issued 2012-09-10
dc.identifier.citation Kumar, Manish; Gayen, Kalyan and Saini, Supreet, “Dynamics and control of the clostridium acetobutylicum metabolic network”, in Clostridium XII International Conference on the Genetics, Physiology and Biotechnology of Solvent and Acid-forming Clostridia, Nottingham, UK, September 10-12, 2012. en_US
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1109
dc.description.abstract Clostridium acetobutylicum is an anaerobic, Gram-positive, spore forming bacteria that is characterized by its unique two-step metabolic pathway. Upon growth in presence of carbon sources, the bacterium first consumes them to produce organic acids in a phase that is known as acidogenesis. Upon accumulation of acids, the organism shuts down acid production, and in fact, consumes the acids to convert them into organic solvents (acetone, butanol, and ethanol). The second phase is called solventogenesis. In this study, using both experimental and computational techniques, we explore the dynamics of the Clostridium metabolic network, and more specifically, the switch from acidogenesis to solventogenesis. Our results show that the two phases are expressed independently of each other, and not in a switch-like manner. We also demonstrate that within each of the two phases, there exists a hierarchy of expression of acids and solvents. We also report presence of negative feedback loops in the network leading to a more complex picture of the Clostridium metabolic network. en_US
dc.description.statementofresponsibility by Manish Kumar, Kalyan Gayen and Supreet Saini
dc.language.iso en en_US
dc.subject Acetobutylicum en_US
dc.subject Anaerobic en_US
dc.subject Clostridium en_US
dc.subject Gram-positive en_US
dc.subject Metabolic network en_US
dc.subject Solventogenesis en_US
dc.title Dynamics and control of the clostridium acetobutylicum metabolic network en_US
dc.type Article en_US


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