Prediction of horseshoe configuration in neural receptors: dscam isoforms

Show simple item record

dc.contributor.author Thiruvenkatam, Vijay
dc.contributor.author Chen, Qiang
dc.contributor.author Wang, Jia-huai
dc.contributor.other 23rd Congress and general assembly of the International Union of Crystallography (IUCr2014)
dc.coverage.spatial Montreal, CA
dc.date.accessioned 2014-08-28T13:20:59Z
dc.date.available 2014-08-28T13:20:59Z
dc.date.issued 2014-08-05
dc.identifier.citation Thiruvenkatam, Vijay; Chen, Q. and Wang, J., "Prediction of horseshoe configuration in neural receptors: dscam isoforms", in 23rd Congress and general assembly of the International Union of Crystallography (IUCr2014), Montreal, CA, Aug. 5-12, 2014 en_US
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1382
dc.description.abstract Dscam (Down Syndrome Cell Adhesion Molecule), a member of immunoglobulin superfamily (IgSF), is a receptor for netrin-1 [1,2], a classical axon guidance cue. The interaction between netrin-1 and Dscam plays an important role in the development of the nervous system. Here, we present the crystal structure of the N-terminal four Ig-like domains of Dscam. The molecule folds into a horseshoe-like configuration. A comparison of this Dscam horseshoe with the previously described horseshoe structures of other cell-surface receptors has revealed fascinating conserved structural features and important sequence markers for these IgSF proteins. This discovery can help us predict the horseshoe configuration N-terminal arrangements in a number of other structurally unknown neural receptors. The N-terminal horseshoe has been shown to be engaged in homophilic and heterophilic interactions between two cell-surface receptors. en_US
dc.description.statementofresponsibility by Vijay Thiruvenkatam, Q. Chen and J. Wang
dc.language.iso en en_US
dc.publisher 23rd Congress and general assembly of the International Union of Crystallography (IUCr2014) en_US
dc.subject Dscam en_US
dc.subject Horseshoe en_US
dc.subject Neural receptors en_US
dc.title Prediction of horseshoe configuration in neural receptors: dscam isoforms en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account