Prediction of horseshoe configuration in neural receptors: Dscam isoforms

Show simple item record Thiruvenkatam, Vijay Chen, Qiang Wang, Jia-huai 2014-11-29T05:43:27Z 2014-11-29T05:43:27Z 2014-11
dc.identifier.citation Thiruvenkatam, Vijay; Chen, Qiang and Wang, Jia-huai, “Prediction of horseshoe configuration in neural receptors: Dscam isoforms”, Acta Crystallographica Section A, DOI: 10.1107/S2053273314084952, vol. 70, no. a1, Aug. 2014. en_US
dc.identifier.issn 2053-2733
dc.description.abstract Dscam (Down Syndrome Cell Adhesion Molecule), a member of immunoglobulin superfamily (IgSF), is a receptor for netrin-1 [1,2], a classical axon guidance cue. The interaction between netrin-1 and Dscam plays an important role in the development of the nervous system. Here, we present the crystal structure of the N-terminal four Ig-like domains of Dscam. The molecule folds into a horseshoe-like configuration. A comparison of this Dscam horseshoe with the previously described horseshoe structures of other cell-surface receptors has revealed fascinating conserved structural features and important sequence markers for these IgSF proteins. This discovery can help us predict the horseshoe configuration N-terminal arrangements in a number of other structurally unknown neural receptors. The N-terminal horseshoe has been shown to be engaged in homophilic and heterophilic interactions between two cell-surface receptors. en_US
dc.description.statementofresponsibility by Vijay Thiruvenkatam, Qiang Chen and Jia-huai Wang
dc.format.extent vol. 70, no. a1
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Dscam en_US
dc.subject Horseshoe en_US
dc.subject Neural receptors en_US
dc.title Prediction of horseshoe configuration in neural receptors: Dscam isoforms en_US
dc.type Article en_US
dc.relation.journal Acta Crystallographica Section A

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