Effect of ultrasound and stabilizers on nucleation kinetics of curcumin during liquid antisolvent precipitation

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dc.contributor.author Dalvi, Sameer V.
dc.contributor.author Yadav, Manishkumar D.
dc.date.accessioned 2015-03-05T08:46:00Z
dc.date.available 2015-03-05T08:46:00Z
dc.date.issued 2015-05
dc.identifier.citation Dalvi, Sameer V. and Yadav, Manishkumar D., “Effect of ultrasound and stabilizers on nucleation kinetics of curcumin during liquid antisolvent precipitation”, Ultrasonics Sonochemistry, DOI: 10.1016/j.ultsonch.2014.11.016, vol. 24, pp. 114-122, May 2015. en_US
dc.identifier.issn 1350-4177
dc.identifier.uri http://dx.doi.org/10.1016/j.ultsonch.2014.11.016
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1632
dc.description.abstract Nucleation kinetics of liquid antisolvent precipitation of a poorly water soluble drug curcumin in presence of ultrasound and surfactants have been estimated. Ultrasound and stabilizers were found to have opposing effects on induction time (τind), metastable zone width (MSZW) and nucleation rates (J) of curcumin during antisolvent precipitation. The use of ultrasound (in presence or absence of stabilizers) was found to decrease τind and MSZW drastically while the values of nucleation rates were found to increase. In contrast to these observations, use of stabilizers (in presence or absence of ultrasound) were found to increase MSZW, increase τind and lower the nucleation rates (J) of curcumin. The solid–liquid interfacial energies (γSL) for curcumin in aqueous ethanolic solutions (with and without stabilizers) have also been calculated using experimentally estimated induction time (τind) and supersaturation data. The values of solid–liquid interfacial energies were found to be in the range of 1.5–3.5 mJ/m2. In comparison to these values, the values of γSL predicted by Mersmann equation and equation proposed by Bennema and Sohnel were found to be significantly higher and were in the range of 10–30 mJ/m2. en_US
dc.description.statementofresponsibility by Sameer V. Dalvi and Manishkumar D. Yadav
dc.format.extent Vol. 24, pp. 114-122
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Curcumin en_US
dc.subject Induction time en_US
dc.subject Interfacial energy en_US
dc.subject Metastable zone width en_US
dc.subject Stabilizers en_US
dc.subject Ultrasound en_US
dc.title Effect of ultrasound and stabilizers on nucleation kinetics of curcumin during liquid antisolvent precipitation en_US
dc.type Article en_US
dc.relation.journal Ultrasonics Sonochemistry


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