Ultrasound-assisted modulation of concomitant polymorphism of curcumin during liquid antisolvent precipitation

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dc.contributor.author Thorat, Alpana Ankush
dc.contributor.author Dalvi, Sameer V.
dc.date.accessioned 2015-12-16T06:20:16Z
dc.date.available 2015-12-16T06:20:16Z
dc.date.issued 2016-05
dc.identifier.citation Thorat, Alpana A. and Dalvi, Sameer V., “Ultrasound-assisted modulation of concomitant polymorphism of curcumin during liquid antisolvent precipitation”, Ultrasonics Sonochemistry, DOI: 10.1016/j.ultsonch.2015.11.025, vol. 30, pp. 35-43, May 2016. [To appear] en_US
dc.identifier.issn 1350-4177
dc.identifier.uri http://dx.doi.org/10.1016/j.ultsonch.2015.11.025
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1998
dc.description.abstract Curcumin polymorphs were found to precipitate concomitantly during liquid antisolvent precipitation. While, commercially available curcumin exists in a monoclinic form, the curcumin particles when precipitated in presence of additives and ultrasound were either found to be the mixtures of orthorhombic (Form 3) and monoclinic form (Form 1) or were found to be in orthorhombic form (Form 3) or monoclinic form (Form 1). The experimentally observed particle morphologies did not match clearly with the predicted BFDH morphologies of curcumin and the experimentally observed morphologies were more elongated as compared to the predicted BFDH morphologies. At lower ultrasonic irradiation times, the monoclinic form (Form 1) was found to dominate the mixture of particles. However, an increase in ultrasonic irradiation time was found to increase the percentage of orthorhombic form (Form 3) in the particles indicating that the increase in ultrasonic energy facilitates formation of orthorhombic form over the monoclinic form, irrespective of the additive used. These results therefore suggest that the ultrasonic energy can be effectively used to manipulate the polymorphic outcome of the precipitation. en_US
dc.description.statementofresponsibility by Alpana A. Thorat and Sameer V. Dalvi
dc.format.extent vol. 30, pp. 35-43
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Curcumin en_US
dc.subject Liquid antisolvent precipitation en_US
dc.subject Polymorphism en_US
dc.subject Concomitant en_US
dc.subject Poorly water soluble drug en_US
dc.subject Additives en_US
dc.title Ultrasound-assisted modulation of concomitant polymorphism of curcumin during liquid antisolvent precipitation en_US
dc.type Article en_US
dc.relation.journal Ultrasonics Sonochemistry


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