Abstract:
We report a concise method for the formal synthesis of trisubstituted γ-butyrolactone by
cross aldol reaction of commercial available aldehyde and -chlorohexanal in presence of
chiral amino acid based organocatalyst. We have synthesized -chlorohexanal by
-chlorination of hexanal by using a chiral catalyst. After three steps, we will reach to our
final goal which is the biologically active (-)-Phaseolinic acid. We had started our
synthesis from γ-butyrolactone which is very cheap and easily available.