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Browsing by Issue Date

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  • Sharma, Vasudha; Thakore, Prachi; Majumdar, Sharmistha (MDPI, 2021-05)
    The catalytic domain of most 'cut and paste' DNA transposases have the canonical RNase-H fold, which is also shared by other polynucleotidyl transferases such as the retroviral integrases and the RAG1 subunit of V(D)J ...
  • Sanghavi, Hiral M.; Majumdar, Sharmistha (American Chemical Society, 2021-05)
    Active DNA transposases like the Drosophila P element transposase (DmTNP) undergo oligomerization as a prerequisite for transposition. Human THAP9 (hTHAP9) is a catalytically active but functionally uncharacterized homologue ...
  • Gediya, Piyush; Vyas, Vivek K.; Carafa, Vincenzo; Sitwala, Nikum; Della Torre, Laura; Poziello, Angelita; Kurohara, Takashi; Suzuki, Takayoshi; Sanna, Vinod; Raguraman, Varalakshmi; Suthindhiran, K.; Ghosh, Debarpan; Bhatia, Dhiraj; Altucci, Lucia; Ghate, Manjunath D. (Elsevier, 2021-05)
    The discovery and development of isoform-selective histone deacetylase (HDAC) inhibitor is a challenging task because of the sequence homology among HDAC enzymes. In the present work, novel tetrahydro benzo[b]thiophene-3 ...
  • Surendra, V. S.; Jayaram, V.; Muruganantham, M.; Thiruvenkatam, Vijay; Vijayan, S.; Samarth, P.; Hill, H.; Bhardwaj, Anil; Mason, N. J.; Sivaraman, B. (Cambridge University Press, 2021-05)
    Nucleobases are nitrogenous bases composed of monomers that are a major constituent of RNA and DNA, which are an essential part of any cellular life on the Earth. The search for nucleobases in the interstellar medium remains ...

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