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Now showing items 83-102 of 127

Nanobiocatalyst facilitated aglycosidic quercetin as a potent inhibitor of tau protein aggregation

Kumar, Sanjay; Guru, Krishnakumar Viswanathan; Morya, Vinod; Gupta, Sharad; Datta, Bhaskar (Elsevier, 2019-10)

Polyphenols have been suggested as potential therapeutic agents for the treatment of amyloidogenic diseases. In this work, we evaluate quercetin-rich onion extract for its ability to inhibit tau fibrillization. Considering ...
Nanomaterials for agricultural and ecological defense applications: active agents and sensors

Sharma, Pramila; Kumar, Sanjay; Patel, Axita; Datta, Bhaskar; DeLong, Robert K. (Wiley, 2021-03)

The world we live in today is overpopulated with an unprecedented number of people competing for fewer and fewer precious resources. The struggle to efficiently steward and manage these resources is a global problem in ...
Nanosheet size-dependent rheology, microstructure, adsorption properties of graphene oxide-electrolyte dispersions and adsorbents

Ojha, Abhijeet; Ibrahim, Helen; Alyabyeva, Natalia; Lazzari, Remi; Goldmann, Michel; Thareja, Prachi (Elsevier, 2020-011)

The variation of lateral dimensions of GO nanosheets by subjecting them to different ultrasonication time (t = 30, 60, and 120 min) influences the rheology, microstructure, and adsorption capacity of graphene oxide (GO) ...
The Neuropsychology of movement and movement disorders: neuroanatomical and cognitive considerations

Haaland, Kathleen Y.; Dum, Richard P.; Mutha, Pratik K.; Strick, Peter L.; Tröster, Alexander I. (Cambridge University Press, 2018-10)

This paper highlights major developments over the past two to three decades in the neuropsychology of movement and its disorders. We focus on studies in healthy individuals and patients, which have identified cognitive ...
Neurotoxic or neuroprotective: post-translational modifications of ?-synuclein at the cross-roads of functions

Gadhavi, Joshna; Patel, Mohini; Bhatia, Dhiraj; Gupta, Sharad (Elsevier, 2022-01)

Parkinson's disease is the second most prevalent neurodegenerative disease. The loss of dopaminergic neurons in the substantia nigra is one of the pathological hallmarks of PD. PD also belongs to the class of neurodegenerative ...
New curcumin-trimesic acid cocrystal and anti-invasion activity of curcumin multicomponent solids against 3D tumor models

Sathisaran, Indumathi; Bhatia, Dhiraj; Dalvi, Sameer V. (Elsevier, 2020-09)

Curcumin (CUR) is a Biopharmaceutics Classification System (BCS) class IV drug with poor aqueous solubility and low permeability. The dissolution of CUR can be enhanced through the cocrystallization approach. In this work, ...
Oligomerization of THAP9 transposase via amino-terminal domains

Sanghavi, Hiral M.; Majumdar, Sharmistha (American Chemical Society, 2021-05)

Active DNA transposases like the Drosophila P element transposase (DmTNP) undergo oligomerization as a prerequisite for transposition. Human THAP9 (hTHAP9) is a catalytically active but functionally uncharacterized homologue ...
One and two?component organogels with cyanostilbene without any auxiliary substituents

Katla, Jagadish; Shaik, Althaf; Dahiwadkar, Rahul; Thiruvenkatam, Vijay; Kanvah, Sriram (Wiley, 2019-12)

Pyridyl acrylonitrile without traditional auxiliary groups form stable organogels in ethanol. The addition of a second non?gelating cyanostilbene component results in a more stable two?component gel. Single crystal X?ray ...
P Transposable Elements in Drosophila and other Eukaryotic Organisms

Majumdar, Sharmistha; Rio, Donald C. (American Society for Microbiology, 2015-04)

P transposable elements were discovered in Drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. Hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the ...
Peptide functionalized DNA hydrogel enhances neuroblastoma cell growth and differentiation

Hivare, Pravin; Gangrade, Ankit; Swarup, Gitanjali; Bhavsar, Krishna; Singh, Ankur; Gupta, Ratnika; Thareja, Prachi; Gupta, Sharad; Bhatia, Dhiraj (Royal Society of Chemistry, 2022-05)

Designing programmable biomaterials that could act as extracellular matrices and permit functionalization is a current need for tissue engineering advancement. DNA based hydrogels are gaining significant attention owing ...
Physical characterization of chitosan/gelatin-alginate composite beads for controlled release of urea

Sathisaran, Indumathi; Balasubramanian, Murugesan (Elsevier, 2020-11)

Polymer-based controlled-release formulations are gaining significant advantage over chemical fertilizers in recent years as they contribute to the preservation of soil fertility by reducing soil pollution in farm lands. ...
Piperazine and DBU: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis

Ralhan, Krittika; Guru, Krishnakumar Viswanathan; Gupta, Sharad (Royal Society of Chemistry, 2015-11)

In Solid Phase Peptide Synthesis (SPPS), contamination with deletion sequences which often co-elute with the target peptide continues to be a major challenge as these impurities can significantly affect the target peptide’s ...
Prediction of horseshoe configuration in neural receptors: Dscam isoforms

Thiruvenkatam, Vijay; Chen, Qiang; Wang, Jia-huai (Wiley, 2014-11)

Dscam (Down Syndrome Cell Adhesion Molecule), a member of immunoglobulin superfamily (IgSF), is a receptor for netrin-1 [1,2], a classical axon guidance cue. The interaction between netrin-1 and Dscam plays an important ...
Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation

Morozova, Olga A.; Gupta, Sharad; Colby, David W. (Science Direct, 2015-07-08)

Many neurodegenerative diseases are associated with deposits of aggregated protein in the brain. The molecular pathways through which soluble proteins misfold to form amyloids and large protein aggregates often include ...
Programmable DNA nanodevices for applications in neuroscience

Hivare, Pravin|Panda, Chinmaya; Gupta, Sharad; Bhatia, Dhiraj (American Chemical Society, 2021-02)

The broad area of neuroscience has witnessed an increasing exploitation of a variety of synthetic biomaterials with controlled nanosized features. Different bionanomaterials offer very peculiar physicochemical and biochemcial ...
Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering

Gangrade, Ankit; Stephanopoulos, Nicholas; Bhatia, Dhiraj (Royal Society of Chemistry, 2021-09)

DNA-based nanotechnology has evolved into an autonomous, highly innovative, and dynamic field of research at the nexus of supramolecular chemistry, nanotechnology, materials science, and biotechnology. DNA-based materials, ...
Promising drug targets and associated therapeutic interventions in Parkinson�s disease

Rai, Sachchidanand; Singh, Payal; Varshney, Ritu; Chaturvedi, Vivek K.; Vamanu, Emanuel; Singh, M.P.; Singh, Brijesh Kumar (Medknow Publications, 2021-01)

Parkinson�s disease (PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD ...
Propagation of forcing and model uncertainties on to hydrological drought characteristics in a multi-model century-long experiment in large river basins

Samaniego, Luis; Kumar, R.; Breuer, L.; Chamorro, Alejandro; Flörke, M.; Pechlivanidis, Ilias G.; Schäfer, D.; Shah, H.; Vetter, T.; Wortmann, Michel; Zeng, Xiaofan (Spriger, 2017-04)

Recent climate change impact studies studies have presented conflicting results regarding the largest source of uncertainty in essential hydrological variables, especially streamflow and derived characteristics that describe ...
Qualitative and quantitative analysis of intermolecular interactions in xanthenedione derivatives

Purushothaman, Gayathri; Thiruvenkatam, Vijay (International Union of Crystallography, 2018-07)

The existence of intermolecular interactions and the conformational geometry adopted by molecules are related to biological activity. Xanthenedione molecules are promising and emerging antioxidants and acetylcholinesterase ...
Recombinant tumor suppressor TSC1 differentially interacts with Escherichia coli DnaK and human HSP70

Natarajan, Nalini; Shaik, Althaf; Thiruvenkatam, Vijay (American Chemical Society, 2020-07)

Tuberous sclerosis complex (TSC) is a neurological syndrome manifested by non-cancerous tumors in several organs. Mutations in either TSC1 or TSC2 tumor suppressor gene cause the disease. In the cell, TSC1 is known to form ...

Now showing items 83-102 of 127

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