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Intranasal exposure to ZnO nanoparticles induces alterations in cholinergic neurotransmission in rat brain

Chakraborty, Swaroop et al. (Elsevier, 2020-12)

The neurotoxicity of inhaled ZnO nanoparticles (NPs) and the underlying mechanisms remain largely unknown. In this study, ZnO NPs (30 � 6 nm) were intranasally instilled to rats via a single dose (13 mg Zn/kg BW), with ...
An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1

Patel, Manthan; Patel, Divyesh; Datta, Subhamoy; Singh, Umashankar (BioMed Central, 2020-12)

Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate ...
DNA-functionalized nanoparticles for targeted biosensing and biological applications

Singh, Udisha; Morya, Vinod; Rajwar, Anjali; Chandrasekaran, Arun Richard; Datta, Bhaskar; Ghoroi, Chinmay; Bhatia, Dhiraj (American Chemical Society, 2020-12)

Nanoscale systems have increasingly been used in biomedical applications, enhancing the demand for the development of biomolecule-functionalized nanoparticles for targeted applications. Such designer nanosystems hold great ...
Diphenyl triazine hybrids inhibit ?-synuclein fibrillogenesis: design, synthesis and in vitro efficacy studies

Maqbool, Mudasir; Gadhavi, Joshna; Hivare, Pravin; Gupta, Sharad; Hoda, Nasimul (Elsevier, 2020-12)

Aggregation of ?-synuclein (?-syn) is one of the central hypotheses for Parkinson's disease (PD), therefore, its inhibition and disaggregation is an optimistic approach for the treatment of PD. Here, we report design, ...

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