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Water stable, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

Singh, Udisha; Guduru Teja, Aditya; Walia, Shanka; Vaswani, Payal; Dalvi, Sameer V.; Bhatia, Dhiraj (Royal Society of Chemistry, 2022-01)

Bright fluorescent nanoparticles with excitation and emission towards the red end of the spectrum are highly desirable in the field of bioimaging. We present here a new class of organic carbon-based nanoparticles (CNPs) ...
Neurotoxic or neuroprotective: post-translational modifications of ?-synuclein at the cross-roads of functions

Gadhavi, Joshna; Patel, Mohini; Bhatia, Dhiraj; Gupta, Sharad (Elsevier, 2022-01)

Parkinson's disease is the second most prevalent neurodegenerative disease. The loss of dopaminergic neurons in the substantia nigra is one of the pathological hallmarks of PD. PD also belongs to the class of neurodegenerative ...
Effect of binding-affinity and ATPase activity on the velocities of kinesins using Ratchet Models

Mukherjee, Rupsha; Soppina, Pushpanjali; Patel, Nishaben; Soppina, Virupakshi; Rane, Kaustubh (Springer, 2022-01)

We use two-state ratchet models containing single and coupled Brownian motors to understand the role of motor-microtubule binding, ATPase reaction rate and dimerisation on the translational velocities of Kinesin motors. ...
CuO nanoparticles as Copper-Ion reservoirs for elesclomol-mediated intracellular oxidative stress: implications for anticancer therapies

Chakraborty, Swaroop; Prakash, Prabhat; Shah, Juhi; Mayya, Chaithra; Singh, Sanjay; Ranganathan, Raghavan; Soppina, Virupakshi; Jones, Eugenia Valsami; Misra, Superb K. (Amercian Chemical Society, 2022-01)

Dissolution of metal/metal oxide nanoparticles has been widely exploited to be one of the mechanisms of inducing oxidative stress within bacterial and mammalian cells. Elesclomol has been already evaluated in clinical ...
Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1

Datta, Subhamoy; Patel, Manthan; Kashyap, Sukesh; Patel, Divyesh; Singh, Umashankar (Impact Journals, 2022-01)

Genomes of somatic cells in culture are prone to spontaneous mutations due to errors in replication and DNA repair. Some of these errors, such as chromosomal fusions, are not rectifiable and subject to selection or elimination ...

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