• Hypoxia modulates cellular endocytic pathways and organelles with enhanced cell migration and 3D cell invasion 

  Naveena, A. Hema; Bhatia, Dhiraj (Cold Spring Harbor Laboratory, 2022-02)

  Hypoxia, a decrease in cellular or tissue level oxygen content, is characteristic of most tumours and shown to drive cancer progression by altering multiple subcellular processes. We hypothesized that the cancer cells in ...
• Self-assembled DNA nanostructures promote cell migration & differentiation of human umbilical vein endothelial cells 

  Rajwar, Anjali; Vaswani, Payal; Bhatia, Dhiraj (Cold Spring Harbor Laboratory, 2022-01)

  DNA nanostructures have been explored for capabilities to influence cellular behavior and its functions. Recent times have seen the development of new emergent functionalities of DNA nanodevices as class of biomaterials ...
• A minimal coarse-grained model to study the gelation of multi-armed DNA nanostars 

  Naskar, Supriyo; Bhatia, Dhiraj; Lin, Shiang-Tai; Maiti, Prabal K. (Cornell University Library, 2021-10)

  DNA is an astonishing material that can be used as a molecular building block to construct periodic arrays and devices with nanoscale accuracy and precision. Here, we present simple bead-spring model of DNA nanostars having ...
• Sunflower-like fluorescent self-assembled morphologies formed by pyridothiazole based aggregation induced emission (AIE) dye and its cell imaging applications 

  Kshtriya, Vivekshinh; Koshti, Bharti; Haque, Ashadul; Gangrade, Ankit; Singh, Ramesh; Joshi, khashti Ballabh; Bandyopadhyay, Sujoy; Bhatia, Dhiraj; Gour, Nidhi (ChemRxiv.org, 2021-02)

  fluorescent sunflower-like architectures. Interestingly, TPA exhibits blue fluorescence in visible light at 385 nm and the fluorescence is not affected by photo-induced quenching rather the fluorescence keeps on increasing ...
• Self-assembly and photophysical studies of an unusual red colored dye which show green fluorescence in cell imaging 

  Kshtriya, Vivekshinh; Koshti, Bharti; Haque, Ashadul; Gangrade, Ankit; Singh, Ramesh; Joshi, khashti Ballabh; Bandyopadhyay, Sujoy; Bhatia, Dhiraj; Gour, Nidhi (ChemRxiv.org, 2021-03)

  We report for the very first time self-assembly of a red color dye 7-Amino-6h-anthra[9,1-cd][1,2]thiazol-6-one (AAT),its photophysical properties and its applications in cell imaging.Interestingly, AAT show intense red ...
• Stress induced Differential Expression of THAP9 & THAP9-AS1 in the S-phase of cell cycle 

  Sharma, Vasudha; Thakore, Prachi; Krishnan, Meena; Majumdar, Sharmistha (Cold Spring Harbor Laboratory, 2021-02)

  Transposable elements function as one of the major effectors in response to biological or environmental stress. Under normal conditions, host organisms deploy epigenetic and post-transcriptional machinery (histone ...
• Synapomorphic variations in the THAP domains of the human THAP protein family and its homologs 

  Sanghavi, Hiral M.; Majumdar, Sharmistha, (Cold Spring Harbor Laboratory, 2021-02)

  The THAP (Thanatos-associated protein) domain is a DNA-binding domain which binds DNA via a zinc coordinating C2CH motif. Although THAP domains share a conserved structural fold, they bind different DNA sequences in different ...
• Amyloid like aggregates formed by the self-assembly of proline and hydroxyproline 

  Koshti, Bharti; Chilwal, Ramesh Singh; Kshtriya, Vivekshinh; Walia, Shanka; Bhatia, Dhiraj; Joshi, K. B.; Gour, Nidhi (ChemRxiv.org, 2021-01)

  Single amino acid based self-assembled structures have gained a lot of interest recently owing to their pathological significance in metabolite disorders. There is plethora of significant research work which illustrate ...
• A novel sensor for sequential and cellular detection of copper and lactic acid 

  Gour, Nidhi; Kharbanda, Sumit; Pandey, Deepak Kumar; Singh, Dheeraj K.; Bhatia, Dhiraj; Kshtriya, Vivek Shinh; Kanth P., Chandra (ChemRxiv.org, 2020-06)
• HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1 

  Patel, Manthan; Patel, Divyesh; Datta, Subhamoy; Singh, Umashankar (Cold Spring Harbor Laboratory, 2020-01)

  The antineoplastic agent Givinostat inhibits histone deacetylases. We present here our finding that the DNA-binding of human CGGBP1 is also inhibited by Givinostat. CGGBP1, a DNA-binding protein, is required for cancer ...
• A new disaggregation induced emission enhancement (DIEE)based probe for cellular detection of copper and lactate 

  Gour, Nidhi; Kshtriya, Vivek Shinh; Singh, Dheeraj K.; kanth P., Chandra; Bhatia, Dhiraj (2019-06)

  We report self assembling/aggregation properties of acyl-thiourea derivative, N-((6-methoxy-pyridin-2-yl)carbamothioyl)benzamide(NG1) [i1] and the disaggregation induced emission which leads to its application as fluorescence ...
• Complex macroscale structures formed by the shock processing of amino acids and nucleobases -- implications to the origins of life 

  Surendra, V. S; Jayaram, V; Karthik, S; Vijayan, S; Chandrasekaran, V; Thombre, R; Thiruvenkatam, Vijay; Raja Sekhar, B. N.; Bhardwaj, A; Jagadeesh, G; Reddy, K P J; Mason, N J; Sivaraman, B (Cornell University Library, 2019-06)

  The building blocks of life, amino acids and nucleobases, are believed to have been synthesized in the extreme conditions that prevail in space starting from simple molecules containing hydrogen, carbon, oxygen and nitrogen. ...
• Evolutionarily conserved regions of THAP9 transposase reveal new motifs for subcellular localization and post-translational modification 

  Rashmi, Richa; Nandi, Chandan; Majumdar, Sharmistha (Cold Spring Harbor Laboratory, 2021-08)

  THAP9 is a transposable element-derived gene that encodes the THAP9 protein. It is a homolog of Drosophila P-element transposase (DmTNP). hTHAP9 belongs to the THAP (Thanatos-associated protein) protein family in humans, ...

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