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Graphene oxide nanocell for impairing topoisomerase and DNA in cancer cells

Nandi, Aditi; Ghosh, Chandramouli; Bajpai, Aman; Basu, Sudipta (Royal Society of Chemistry, 2019-05)

DNA Topoisomerases and nuclear DNA are important targets for cancer therapy. However, DNA Topoisomerase inhibitors and DNA damaging drugs demonstrate a large window of side effects in the clinics. Graphene oxide based ...
Lipid nanoparticle-mediated induction of endoplasmic reticulum stress in cancer sells

Ghosh, Chandramouli; Nandi, Aditi; Basu, Sudipta (American Chemical Society, 2019-08)

The endoplasmic reticulum (ER) primarily guides protein synthesis, folding, transport, and lipid biosynthesis inside the cells. As a result, dysregulation in those cellular functions leading to ER stress has recently emerged ...
Polymer conjugated graphene-oxide nanoparticles impair nuclear DNA and Topoisomerase I in cancer

Nandi, Aditi; Ghosh, Chandramouli; Basu, Sudipta (Royal Society of Chemistry, 2019-11)

Cancer chemotherapy had been dominated by the use of small molecule DNA damaging drugs. Eventually, the emergence of DNA damage repair machinery in cancer cells has led to combination therapy with the DNA topology controlling ...
Supramolecular self-assembly of triazine-based small molecule: targeting endoplasmic reticulum in cancer cells

Ghosh, Chandramouli; Nandi, Aditi; Basu, Sudipta (Royal Society of Chemistry, 2019-01)

The endoplasmic reticulum (ER) is one of the most important organelles controlling myriads of cellular functions including protein folding/misfolding/unfolding, calcium ion homeostasis and lipid biosynthesis. Subsequently, ...

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