We report a concise method for the formal synthesis of trisubstituted γ-butyrolactone by cross aldol reaction of commercial available aldehyde and -chlorohexanal in presence of chiral amino acid based organocatalyst. ...

Selectively alkylating an alpha beta unsaturated aldehyde at gamma position has been a challenging task. It is very difficult to obtain high regio- as well as Enantio-selectivity at this place. A comprehensive amount of ...