Curcumin eutectics with enhanced dissolution rates: binary phase diagrams, characterization, and dissolution studies

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dc.contributor.author Sathisaran, Indumathi
dc.contributor.author Skieneh, Jenna Marie
dc.contributor.author Rohani, Sohrab
dc.contributor.author Dalvi, Sameer V.
dc.date.accessioned 2018-10-04T12:52:45Z
dc.date.available 2018-10-04T12:52:45Z
dc.date.issued 2018-09
dc.identifier.citation Sathisaran, Indumathi; Skieneh, Jenna Marie; Rohani, Sohrab and Dalvi, Sameer Vishvanath, "Curcumin eutectics with enhanced dissolution rates: binary phase diagrams, characterization, and dissolution studies", Journal of Chemical & Engineering Data, DOI: 10.1021/acs.jced.7b01105, Sep. 2018. en_US
dc.identifier.issn 0021-9568
dc.identifier.issn 1520-5134
dc.identifier.uri https://doi.org/10.1021/acs.jced.7b01105
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/3937
dc.description.abstract Curcumin is a potentially viable pharmaceutical ingredient obtained from the rhizome of a turmeric plant, Curcuma longa. It is a polyphenolic compound which is known to possess antibacterial, anti-inflammatory, antitumor, and anticancer properties. Its use in pharmaceutical applications has been limited because of its poor aqueous solubility and hence poor bioavailability. In this work, attempts were made to formulate new solid forms of Curcumin with several coformers, mainly to enhance the dissolution rate of curcumin in aqueous medium. Ibuprofen, succinic acid, paracetamol, carbamazepine, ethyl paraben, glycine, tyrosine, N-acetyl d,l-tryptophan and biotin are the coformers investigated in this study. Binary phase diagrams were constructed for each binary system which helped in identifying the nature and the composition of the solid phase. All binary systems except curcumin–ibuprofen exhibited eutectic formation. The curcumin–ibuprofen system resulted in a physical mixture. These solid phases were further characterized through powder X-ray diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy and Raman spectroscopy. Dissolution studies conducted for eutectics showed enhanced dissolution rates as compared to raw curcumin. The results obtained were compared with the literature reports to present a consolidated account of research being conducted to enhance aqueous solubility of curcumin by developing new solid forms of curcumin such as eutectics, coamorphous solids, and cocrystals. Further, attempts have been made to understand how molecular geometry and intermolecular interactions influence the formation of a specific solid form.
dc.description.statementofresponsibility by Indumathi Sathisaran, Jenna Marie Skieneh,Sohrab Rohani and Sameer Vishvanath Dalvi
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.subject Curcumin en_US
dc.subject Binary Phase Diagrams en_US
dc.subject Dissolution Studies en_US
dc.title Curcumin eutectics with enhanced dissolution rates: binary phase diagrams, characterization, and dissolution studies en_US
dc.type Article en_US
dc.relation.journal Journal of Chemical & Engineering Data


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