Polyethylenimine coated graphene-oxide nanoparticles for targeting mitochondria in cancer cells

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dc.contributor.author Mallick, Abhik
dc.contributor.author Nandi, Aditi
dc.contributor.author Basu, Sudipta
dc.date.accessioned 2019-01-16T07:49:19Z
dc.date.available 2019-01-16T07:49:19Z
dc.date.issued 2018-12
dc.identifier.citation Mallick, Abhik; Nandi, Aditi and Basu, Sudipta, "Polyethylenimine coated graphene-oxide nanoparticles for targeting mitochondria in cancer cells", ACS Applied Bio Materials, DOI: 10.1021/acsabm.8b00519, Dec. 2018. en_US
dc.identifier.issn 2576-6422
dc.identifier.issn 2576-6422
dc.identifier.uri https://doi.org/10.1021/acsabm.8b00519
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/4213
dc.description.abstract Mitochondrion, the powerhouse of the cells, controls bioenergetics, biosynthesis, metabolism, and signaling. Consequently, it has become an unorthodox target for cancer therapeutics. However, specific targeting of mitochondria into subcellular milieu in cancer cells remains a major challenge. To address this, we have engineered polyethylenimine cloaked positively charged self-assembled graphene oxide nanoparticle (PEI-GTC-NP) comprising topotecan and cisplatin concurrently. These PEI-GTC-NPs effectively homed into mitochondria in HeLa cervical cancer cells at 6 h and impaired mitochondria leading to reactive oxygen species generation followed by remarkably improved cancer cell death. This platform can be used for specific subcellular organelle targeting for future cancer therapy.
dc.description.statementofresponsibility by Abhik Mallick, Aditi Nandi and Sudipta Basu
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.subject Mitochondria en_US
dc.subject Graphene oxide en_US
dc.subject Nanoparticle en_US
dc.subject Cisplatin en_US
dc.subject DNA damage en_US
dc.subject Cancer en_US
dc.title Polyethylenimine coated graphene-oxide nanoparticles for targeting mitochondria in cancer cells en_US
dc.type Article en_US
dc.relation.journal ACS Applied Bio Materials


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