A possible explanation of how high-frequency deep brain stimulation suppresses low-frequency tremors in Parkinson�s disease

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dc.contributor.author Shah, Vrutangkumar V.
dc.contributor.author Goyal, Sachin
dc.contributor.author Palanthandalam-Madapusi, Harish J.
dc.date.accessioned 2019-06-19T11:12:56Z
dc.date.available 2019-06-19T11:12:56Z
dc.date.issued 2017-08
dc.identifier.citation Shah, Vrutangkumar V.; Goyal, Sachin and Palanthandalam-Madapusi, Harish J., "A possible explanation of how high-frequency deep brain stimulation suppresses low-frequency tremors in Parkinson�s disease", Physical Review D, DOI: 10.1109/TNSRE.2017.2746623, vol. 25, no. 12, pp. 2498-2508, Aug. 2017. en_US
dc.identifier.issn 1534-4320
dc.identifier.issn 1558-0210
dc.identifier.uri https://doi.org/10.1109/TNSRE.2017.2746623
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/4510
dc.description.abstract Parkinson's disease (PD) is a neurodegenerative disorder of the central nervous system and one of its key symptoms is rest tremor. Deep brain stimulation (DBS) effectively suppresses rest tremor in Parkinson's disease. Despite being a successful treatment option, its underlying principle and the mechanism by which it attenuates tremors is not yet fully understood. Since existing methods for tuning DBS parameters are largely trial and error, understanding how DBS works can help to reduce time and costs, and could also ultimately lead to better treatment strategies for PD. In this paper, we set out to analyze how a high-frequency stimulation applied through DBS can help reduce the low-frequency rest tremors observed in PD patients. We identify key elements in the sensorimotor loop (the feedback loop consisting of sensory feedbacks and motor responses) that play a role in the interaction of high-frequency DBS signal and the low-frequency tremor. Based on the analysis of these elements, we draw insights about the working of DBS and the role of frequency and the nature of stimulation. We verify these observations with numerical examples and a bench top experimental example.
dc.description.statementofresponsibility by Vrutangkumar V. Shah, Sachin Goyal and Harish J. Palanthandalam-Madapusi
dc.format.extent vol. 25, no. 12, pp. 2498-2508
dc.language.iso en en_US
dc.publisher IEEE en_US
dc.subject Brain stimulation en_US
dc.subject Parkinson's disease en_US
dc.subject Satellite broadcasting en_US
dc.subject Delays en_US
dc.subject Central nervous system en_US
dc.subject Mechanical engineering en_US
dc.title A possible explanation of how high-frequency deep brain stimulation suppresses low-frequency tremors in Parkinson�s disease en_US
dc.type Article en_US
dc.relation.journal Physical Review D


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